T cell ignorance in mice to Borna disease virus can be overcome by peripheral expression of the viral nucleoprotein
about
The bicolored white-toothed shrew Crocidura leucodon (HERMANN 1780) is an indigenous host of mammalian Borna disease virusBorna disease virus phosphoprotein represses p53-mediated transcriptional activity by interference with HMGB1The pathogenesis of bornaviral diseases in mammals.Neutralizing antibodies in persistent borna disease virus infection: prophylactic effect of gp94-specific monoclonal antibodies in preventing encephalitisCD8(+) T lymphocytes mediate Borna disease virus-induced immunopathology independently of perforinAlpha/beta interferon promotes transcription and inhibits replication of borna disease virus in persistently infected cells.Enhanced neurovirulence of borna disease virus variants associated with nucleotide changes in the glycoprotein and L polymerase genes.Cerebral expression of interleukin-12 induces neurological disease via differential pathways and recruits antigen-specific T cells in virus-infected mice.T cells cause acute immunopathology and are required for long-term survival in mouse adenovirus type 1-induced encephalomyelitisAntiviral CD8 T cells recognize borna disease virus antigen transgenically expressed in either neurons or astrocytesTransgenic mice expressing the nucleoprotein of Borna disease virus in either neurons or astrocytes: decreased susceptibility to homotypic infection and disease.Interferon-gamma prevents death of bystander neurons during CD8 T cell responses in the brain.Viral vector vaccines expressing nucleoprotein and phosphoprotein genes of avian bornaviruses ameliorate homologous challenge infections in cockatiels and common canariesAvian bornavirus associated with fatal disease in psittacine birds.Animal models of CNS viral disease: examples from borna disease virus models.Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation.Identification of the immunodominant H-2K(k)-restricted cytotoxic T-cell epitope in the Borna disease virus nucleoprotein.Borna disease virus accelerates inflammation and disease associated with transgenic expression of interleukin-12 in the central nervous system.Borna disease virus multiplication in mouse organotypic slice cultures is site-specifically inhibited by gamma interferon but not by interleukin-12.CD8 T cells require gamma interferon to clear borna disease virus from the brain and prevent immune system-mediated neuronal damage.Downregulation of an astrocyte-derived inflammatory protein, S100B, reduces vascular inflammatory responses in brains persistently infected with Borna disease virus.Pathogenic potential of borna disease virus lacking the immunodominant CD8 T-cell epitope.
P2860
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P2860
T cell ignorance in mice to Borna disease virus can be overcome by peripheral expression of the viral nucleoprotein
description
1999 nî lūn-bûn
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1999年の論文
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1999年学术文章
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1999年学术文章
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1999年学术文章
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1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
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1999年學術文章
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name
T cell ignorance in mice to Bo ...... ion of the viral nucleoprotein
@ast
T cell ignorance in mice to Bo ...... ion of the viral nucleoprotein
@en
type
label
T cell ignorance in mice to Bo ...... ion of the viral nucleoprotein
@ast
T cell ignorance in mice to Bo ...... ion of the viral nucleoprotein
@en
prefLabel
T cell ignorance in mice to Bo ...... ion of the viral nucleoprotein
@ast
T cell ignorance in mice to Bo ...... ion of the viral nucleoprotein
@en
P2093
P2860
P356
P1476
T cell ignorance in mice to Bo ...... ion of the viral nucleoprotein
@en
P2093
A Pagenstecher
C Zimmermann
J C de la Torre
J Hausmann
P Staeheli
W Hallensleben
P2860
P304
P356
10.1073/PNAS.96.17.9769
P407
P577
1999-08-01T00:00:00Z