Role of an S4-S5 linker in sodium channel inactivation probed by mutagenesis and a peptide blocker.
about
A1152D mutation of the Na+ channel causes paramyotonia congenita and emphasizes the role of DIII/S4-S5 linker in fast inactivationThe Hodgkin-Huxley heritage: from channels to circuitsResurgent current of voltage-gated Na(+) channelsHelix-stabilizing effects of the pentapeptide KIFMK and its related peptides on the sodium channel inactivation gate peptides.Interaction between the sodium channel inactivation linker and domain III S4-S5.Defective fast inactivation recovery and deactivation account for sodium channel myotonia in the I1160V mutant.1H-NMR and circular dichroism spectroscopic studies on changes in secondary structures of the sodium channel inactivation gate peptides as caused by the pentapeptide KIFMK.Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating.Genetic disorders of neuromuscular ion channels.Kinetic analysis of block of open sodium channels by a peptide containing the isoleucine, phenylalanine, and methionine (IFM) motif from the inactivation gate.Charge immobilization of skeletal muscle Na+ channels: role of residues in the inactivation linkerTime-dependent block and resurgent tail currents induced by mouse beta4(154-167) peptide in cardiac Na+ channels.Molecular analysis of the putative inactivation particle in the inactivation gate of brain type IIA Na+ channels.Glutamine substitution at alanine1649 in the S4-S5 cytoplasmic loop of domain 4 removes the voltage sensitivity of fast inactivation in the human heart sodium channelInactivation and secondary structure in the D4/S4-5 region of the SkM1 sodium channel.Anomalous effect of permeant ion concentration on peak open probability of cardiac Na+ channels.Effect of alkali metal cations on slow inactivation of cardiac Na+ channels.Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domainsMovement of voltage sensor S4 in domain 4 is tightly coupled to sodium channel fast inactivation and gating charge immobilizationSodium channel inactivation in heart: a novel role of the carboxy-terminal domain.Modulation of cardiac Na(+) and Ca(2+) currents by CaM and CaMKII.A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism.Interactions among DIV voltage-sensor movement, fast inactivation, and resurgent Na current induced by the NaVβ4 open-channel blocking peptideThe external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channelCharacterization of a novel Nav1.5 channel mutation, A551T, associated with Brugada syndrome.Molecular Pathophysiology of Congenital Long QT Syndrome.Resurgent Na currents in four classes of neurons of the cerebellum.On mutations that uncouple sodium channel activation from inactivation.Inwardly permeating Na ions generate the voltage dependence of resurgent Na current in cerebellar Purkinje neurons.Intracellular calcium attenuates late current conducted by mutant human cardiac sodium channels.Oxidation of multiple methionine residues impairs rapid sodium channel inactivation.A human muscle Na+ channel mutation in the voltage sensor IV/S4 affects channel block by the pentapeptide KIFMK.A critical role for the S4-S5 intracellular loop in domain IV of the sodium channel alpha-subunit in fast inactivation.Solution structures of the cytoplasmic linkers between segments S4 and S5 (S4-S5) in domains III and IV of human brain sodium channels in SDS micelles.Mechanisms of Drug Binding to Voltage-Gated Sodium Channels.Interaction of DPP10a with Kv4.3 channel complex results in a sustained current component of human transient outward current Ito.
P2860
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P2860
Role of an S4-S5 linker in sodium channel inactivation probed by mutagenesis and a peptide blocker.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Role of an S4-S5 linker in sod ...... genesis and a peptide blocker.
@ast
Role of an S4-S5 linker in sod ...... genesis and a peptide blocker.
@en
type
label
Role of an S4-S5 linker in sod ...... genesis and a peptide blocker.
@ast
Role of an S4-S5 linker in sod ...... genesis and a peptide blocker.
@en
prefLabel
Role of an S4-S5 linker in sod ...... genesis and a peptide blocker.
@ast
Role of an S4-S5 linker in sod ...... genesis and a peptide blocker.
@en
P2093
P356
P1476
Role of an S4-S5 linker in sod ...... genesis and a peptide blocker.
@en
P2093
P304
P356
10.1085/JGP.108.2.89
P577
1996-08-01T00:00:00Z