Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel.
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Identification of the molecular site of ivabradine binding to HCN4 channelsStructural basis for modulation and agonist specificity of HCN pacemaker channelsThe voltage-dependent gate in MthK potassium channels is located at the selectivity filterLigand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channelDissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the KtrAB K+ TransporterThe pore helix is involved in stabilizing the open state of inwardly rectifying K+ channels.Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype.Defining the physical gate of a mechanosensitive channel, MscL, by engineering metal-binding sites.Ion channel associated diseases: overview of molecular mechanismsA homology model of the pore region of HCN channels.The search is on for the voltage sensor-to-gate coupling.cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.Gating mechanism of KATP channels: function fits form.Disulfide trapping the mechanosensitive channel MscL into a gating-transition state.Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel.Structural changes during HCN channel gating defined by high affinity metal bridges.Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents.Reversal of HCN channel voltage dependence via bridging of the S4-S5 linker and Post-S6.Evidence for a deep pore activation gate in small conductance Ca2+-activated K+ channels.Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate.S4 movement in a mammalian HCN channel.Movements near the gate of a hyperpolarization-activated cation channelLigand-induced closure of inward rectifier Kir6.2 channels traps spermine in the poreCurrent-dependent block of rabbit sino-atrial node I(f) channels by ivabradineLocalization of the activation gate of a voltage-gated Ca2+ channel.Spatial positioning of CFTR's pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathwayIntracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.The analysis of desensitizing CNGA1 channels reveals molecular interactions essential for normal gatingBiochemical and structural analysis of the hyperpolarization-activated K(+) channel MVPA slick, slack pathway through the pore.Mechanism of electromechanical coupling in voltage-gated potassium channels.Metal bridges to probe membrane ion channel structure and function.HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition.On the mechanism of TBA block of the TRPV1 channel.Structural elements of instantaneous and slow gating in hyperpolarization-activated cyclic nucleotide-gated channels.Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels.Ion binding in the open HCN pacemaker channel pore: fast mechanisms to shape "slow" channels.Capturing ion channel gating: a little salt on the tail does the trick.
P2860
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P2860
Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Voltage-controlled gating at t ...... tion-activated cation channel.
@ast
Voltage-controlled gating at t ...... tion-activated cation channel.
@en
type
label
Voltage-controlled gating at t ...... tion-activated cation channel.
@ast
Voltage-controlled gating at t ...... tion-activated cation channel.
@en
prefLabel
Voltage-controlled gating at t ...... tion-activated cation channel.
@ast
Voltage-controlled gating at t ...... tion-activated cation channel.
@en
P2093
P2860
P356
P1476
Voltage-controlled gating at t ...... tion-activated cation channel.
@en
P2093
Brad S Rothberg
Gary Yellen
Ki Soon Shin
Prashant S Phale
P2860
P356
10.1085/JGP.119.1.83
P577
2002-01-01T00:00:00Z