A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation. - Wikidata - awgldk - TriplyDB

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

http://www.wikidata.org/entity/Q36446183

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Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma Contemporary murine models in preclinical astrocytoma drug development New IDH1 mutant inhibitors for treatment of acute myeloid leukemia The Emergence of Pan-Cancer CIMP and Its Elusive Interpretation Oncometabolites: tailoring our genes 2-Hydoxyglutarate: D/Riving Pathology in gLiomaS Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases Precise Detection of IDH1/2 and BRAF Hotspot Mutations in Clinical Glioma Tissues by a Differential Calculus Analysis of High-Resolution Melting Data Molecular pathology of bone tumours: diagnostic implications.Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas.Gene mutations and molecularly targeted therapies in acute myeloid leukemia.Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.The future of high-grade glioma: Where we are and where are we going.Micro-environment causes reversible changes in DNA methylation and mRNA expression profiles in patient-derived glioma stem cells Recurrent 12q13-15 chromosomal aberrations, high frequency of isocitrate dehydrogenase 1 mutations, and absence of high mobility group AT-hook 2 expression in periosteal chondromas.Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs.TET proteins and 5-methylcytosine oxidation in hematological cancers Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas.Histone 3 lysine 9 trimethylation is differentially associated with isocitrate dehydrogenase mutations in oligodendrogliomas and high-grade astrocytomas What do we know about IDH1/2 mutations so far, and how do we use it?COHCAP: an integrative genomic pipeline for single-nucleotide resolution DNA methylation analysis.Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2.Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.Metabolism and epigenetics.Characterizing DNA methylation alterations from The Cancer Genome Atlas.Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG.Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism Glioma: experimental models and reality.Metabolic modulation of epigenetics in gliomas.Metabolic alteration in tumorigenesis.DNA methylation accumulation and its predetermination of future cancer phenotypes.Extracellular vesicles shed by glioma cells: pathogenic role and clinical value.

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A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

http://www.wikidata.org/entity/Q36446183

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

@ast

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

@en

type

label

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

@ast

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

@en

prefLabel

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

@ast

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

@en

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Genome Research

P1476

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation

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P2093

Carlo Rago

http://www.w3.org/2001/XMLSchema#string

Darell D Bigner

http://www.w3.org/2001/XMLSchema#string

Doris R Powell

http://www.w3.org/2001/XMLSchema#string

Genglin Jin

http://www.w3.org/2001/XMLSchema#string

Hai Yan

http://www.w3.org/2001/XMLSchema#string

Jen-Tsan Chi

http://www.w3.org/2001/XMLSchema#string

Paula M Vertino

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Priya Kapoor-Vazirani

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P2860

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Comprehensive analysis of CpG islands in human chromosomes 21 and 22

Improved methods for the generation of human gene knockout and knockin cell lines

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

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2339-2355

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scholarly article

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10.1101/GR.132738.111

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12

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22

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Benjamin G Barwick

Christopher G Duncan

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2012-08-16T00:00:00Z

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230685829

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22899282

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DNA methylation

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3514664

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