Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice.
about
Pathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studiesPalmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine developmentCellular origins of auditory event-related potential deficits in Rett syndromeAMPA receptor antagonist NBQX attenuates later-life epileptic seizures and autistic-like social deficits following neonatal seizuresMapping pathological phenotypes in a mouse model of CDKL5 disorderTargeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits.Molecular and genetic insights into an infantile epileptic encephalopathy - CDKL5 disorder.Searching for biomarkers of CDKL5 disorder: early-onset visual impairment in CDKL5 mutant mice.Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling.Synaptic synthesis, dephosphorylation, and degradation: a novel paradigm for an activity-dependent neuronal control of CDKL5CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization.Characterisation of CDKL5 Transcript Isoforms in Human and MouseSequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth.PreImplantation Factor bolsters neuroprotection via modulating Protein Kinase A and Protein Kinase C signaling.Protease induced plasticity: matrix metalloproteinase-1 promotes neurostructural changes through activation of protease activated receptor 1Proteomic Analysis of Post-synaptic Density Fractions from Shank3 Mutant Mice Reveals Brain Region Specific Changes Relevant to Autism Spectrum Disorder.Synaptic plasticity and signaling in Rett syndrome.Autism genetics - an overview.Lack of Cdkl5 Disrupts the Organization of Excitatory and Inhibitory Synapses and Parvalbumin Interneurons in the Primary Visual Cortex.Translational use of event-related potentials to assess circuit integrity in ASD.APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures.CDKL5 knockout leads to altered inhibitory transmission in the cerebellum of adult mice.CDKL5 localizes at the centrosome and midbody and is required for faithful cell division.The 3' UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse.CDKL5 variants: Improving our understanding of a rare neurologic disorder.Mice lacking cyclin-dependent kinase-like 5 manifest autistic and ADHD-like behaviors.Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation.Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice.Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory.Functional abilities in children and adults with the CDKL5 disorder.Utilizing Animal Models of Infantile Spasms.Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder.
P2860
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P2860
Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Loss of CDKL5 disrupts kinome ...... istic-like phenotypes in mice.
@ast
Loss of CDKL5 disrupts kinome ...... istic-like phenotypes in mice.
@en
type
label
Loss of CDKL5 disrupts kinome ...... istic-like phenotypes in mice.
@ast
Loss of CDKL5 disrupts kinome ...... istic-like phenotypes in mice.
@en
prefLabel
Loss of CDKL5 disrupts kinome ...... istic-like phenotypes in mice.
@ast
Loss of CDKL5 disrupts kinome ...... istic-like phenotypes in mice.
@en
P2093
P2860
P356
P1476
Loss of CDKL5 disrupts kinome ...... tistic-like phenotypes in mice
@en
P2093
Andrew H Fairless
Edward S Brodkin
Eric D Marsh
I-Ting Judy Wang
Julie A Blendy
Megan Allen
Xinjian Zhu
Zhaolan Zhou
P2860
P304
21516-21521
P356
10.1073/PNAS.1216988110
P407
P577
2012-12-10T00:00:00Z