Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. - Wikidata - awgldk - TriplyDB

Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling.

Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling.

http://www.wikidata.org/entity/Q36547655

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Specification and function of hemogenic endothelium during embryogenesis Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells.Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo.Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.Single cell transcriptomics reveals unanticipated features of early hematopoietic precursors PTEN mediates Notch-dependent stalk cell arrest in angiogenesis Basic fibroblast growth factor reduces scar by inhibiting the differentiation of epidermal stem cells to myofibroblasts via the Notch1/Jagged1 pathway.An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer.The role of GATA2 in lethal prostate cancer aggressiveness.The Cebpa +37-kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells.Haematopoietic and immune defects associated with GATA2 mutation.Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells High-Throughput siRNA Screening to Reveal GATA-2 Upstream Transcriptional Mechanisms in Hematopoietic Cells.Uncovering the pathways underlying whole body regeneration in a chordate model, Botrylloides leachi using de novo transcriptome analysis.GATA2 is required for lymphatic vessel valve development and maintenance.Notch signal strength controls cell fate in the haemogenic endothelium GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis.Effects of Developmental Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Long-term Self-renewal of Murine Hematopoietic Stem Cells.The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.Complex regulation of HSC emergence by the Notch signaling pathway.Endothelial-to-hematopoietic transition: Notch-ing vessels into blood.Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence.Developing HSCs become Notch independent by the end of maturation in the AGM region.HOXA4 provides stronger engraftment potential to short-term repopulating cells than HOXB4.Chemokine polyreactivity of IL7Rα+CSF-1R+ lympho-myeloid progenitors in the developing fetal liver Context-dependent enhancer selection confers alternate modes of notch regulation on argos.Tracing the origin of the HSC hierarchy reveals an SCF-dependent, IL-3-independent CD43(-) embryonic precursor.Hes1 suppresses acute myeloid leukemia development through FLT3 repression.Chronic lymphocytic leukemia cells in lymph nodes show frequent NOTCH1 activation.In vivo single cell analysis reveals Gata2 dynamics in cells transitioning to hematopoietic fate.A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation.Olfactory Ensheathing Cells Inhibit Gliosis in Retinal Degeneration by Downregulation of the Müller Cell Notch Signaling Pathway.GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis.Inhibition of Notch3 prevents monocrotaline-induced pulmonary arterial hypertension.The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate.NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.

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P2860

Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling.

http://www.wikidata.org/entity/Q36547655

description

2012 nî lūn-bûn

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2012年論文

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Hes repressors are essential r ...... downstream of Notch signaling.

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Hes repressors are essential r ...... downstream of Notch signaling.

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Hes repressors are essential r ...... downstream of Notch signaling.

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Hes repressors are essential r ...... downstream of Notch signaling.

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Hes repressors are essential r ...... downstream of Notch signaling.

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Hes repressors are essential r ...... downstream of Notch signaling.

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Journal of Experimental Medicine

P1476

Hes repressors are essential r ...... downstream of Notch signaling

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P2093

Elaine Dzierzak

http://www.w3.org/2001/XMLSchema#string

Emery H Bresnick

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Jun Hatakeyama

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Lluis Espinosa

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Masayuki Yamamoto

http://www.w3.org/2001/XMLSchema#string

Ritsuko Shimizu

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Ryoichiro Kageyama

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P2860

Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression

Structure and function of the feed-forward loop network motif

Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop

HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo

The Hes gene family: repressors and oscillators that orchestrate embryogenesis

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells

Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis

P304

71-84

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scholarly article

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10.1084/JEM.20120993

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P433

1

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P478

210

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Stuart T. Fraser

Anna Bigas Salvans

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2012-12-24T00:00:00Z

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233984489

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23267012

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3549704

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