Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts
about
P1343
Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblastsSuppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex.The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteinsRegulation of p16CDKN2 expression and its implications for cell immortalization and senescenceCellular Senescence:Ex Vivop53-Dependent Asymmetric Cell KineticsMolecular interactions between telomerase and the tumor suppressor protein p53 in vitroInactivation of p53 and life span extension of human diploid fibroblasts by mot-2The Y-box-binding protein, YB1, is a potential negative regulator of the p53 tumor suppressorThe proline-rich region of mouse p53 influences transactivation and apoptosis but is largely dispensable for these functions.A reassessment of the telomere hypothesis of senescence.Cell cycle control, checkpoint mechanisms, and genotoxic stress.Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase.HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a.A new functional classification of tumor-suppressing genes and its therapeutic implications.The role of senescence and immortalization in carcinogenesis.Telomere Biology-Insights into an Intriguing Phenomenon.Physical and functional interaction between p53 and the Werner's syndrome protein.The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts.Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts.Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristicsUncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblastsDNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.A mutation in the STN1 gene triggers an alternative lengthening of telomere-like runaway recombinational telomere elongation and rapid deletion in yeast.Alternative lengthening of telomeres in mammalian cells.Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts.Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency.Telomere maintenance mechanisms in cancer: clinical implicationsLi-Fraumeni syndrome--a molecular and clinical review.Long telomeres produced by telomerase-resistant recombination are established from a single source and are subject to extreme sequence scramblingHuman Rad51 protein displays enhanced homologous pairing of DNA sequences resembling those at genetically unstable lociDisruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres.Recombination can cause telomere elongations as well as truncations deep within telomeres in wild-type Kluyveromyces lactis cellsCPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translationYeast telomeres exert a position effect on recombination between internal tracts of yeast telomeric DNACyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanismRelationship between the expression of human telomerase reverse transcriptase gene and cell cycle regulators in gastric cancer and its significanceMaintenance of very long telomeres by recombination in the Kluyveromyces lactis stn1-M1 mutant involves extreme telomeric turnover, telomeric circles, and concerted telomeric amplification.Chromosome end elongation by recombination in the mosquito Anopheles gambiae.
P2860
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P2860
Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Alterations in p53 and p16INK4 ...... -Fraumeni syndrome fibroblasts
@ast
Alterations in p53 and p16INK4 ...... -Fraumeni syndrome fibroblasts
@en
type
label
Alterations in p53 and p16INK4 ...... -Fraumeni syndrome fibroblasts
@ast
Alterations in p53 and p16INK4 ...... -Fraumeni syndrome fibroblasts
@en
prefLabel
Alterations in p53 and p16INK4 ...... -Fraumeni syndrome fibroblasts
@ast
Alterations in p53 and p16INK4 ...... -Fraumeni syndrome fibroblasts
@en
P2093
P2860
P356
P1476
Alterations in p53 and p16INK4 ...... -Fraumeni syndrome fibroblasts
@en
P2093
Dalla-Pozza L
Englezou A
Warneford SG
P2860
P304
P356
10.1128/MCB.15.9.4745
P407
P4510
P577
1995-09-01T00:00:00Z