Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype. - Wikidata - awgldk - TriplyDB

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

http://www.wikidata.org/entity/Q36562956

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Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation The tumor suppressor hTid1 inhibits STAT5b activity via functional interaction Neurological phenotype in Waardenburg syndrome type 4 correlates with novel SOX10 truncating mutations and expression in developing brain.Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Inhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemia Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity Conversion of threonine 757 to valine enhances Stat5a transactivation potential STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor.Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells.Neurotensin stimulates mitogenesis of prostate cancer cells through a novel c-Src/Stat5b pathway.Distinct gene-expression profiles characterize mammary tumors developed in transgenic mice expressing constitutively active and C-terminally truncated variants of STAT5.A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B.The role of STATs in myeloid differentiation and leukemia.Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes.The different functions of Stat5 and chromatin alteration through Stat5 proteins Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens.Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein.Jak2-Stat5 interactions analyzed in yeast.Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5 STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression.Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression Proteasome-dependent down-regulation of activated Stat5A in the nucleus.C/EBPβ promotes BCR-ABL-mediated myeloid expansion and leukemic stem cell exhaustion.Regulation of STAT signalling by proteolytic processing.Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition.Progesterone induction of the 11beta-hydroxysteroid dehydrogenase type 2 promoter in breast cancer cells involves coordinated recruitment of STAT5A and progesterone receptor to a distal enhancer and polymerase tracking Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V.Differential function of STAT5 isoforms in head and neck cancer growth control.The protein arginine methyltransferases CARM1 and PRMT1 cooperate in gene regulation Expression of a tyrosine phosphorylated, DNA binding Stat3beta dimer in bacteria.Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes.A STAT inhibitor patent review: progress since 2011.Acetylation Modulates IL-2 Receptor Signaling in T Cells.Suppressor of cytokine signaling 1 modulates invasion and metastatic potential of colorectal cancer cells.Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation.Evidence for a protective role of the STAT5 transcription factor against oxidative stress in human leukemic pre-B cells.Design of conditionally active STATs: insights into STAT activation and gene regulatory function.

P2860

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P2860

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

http://www.wikidata.org/entity/Q36562956

description

1996 nî lūn-bûn

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1996年の論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年论文

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1996年论文

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1996年论文

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name

Deletion of the carboxyl-termi ...... a dominant negative phenotype.

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Deletion of the carboxyl-termi ...... a dominant negative phenotype.

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type

label

Deletion of the carboxyl-termi ...... a dominant negative phenotype.

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Deletion of the carboxyl-termi ...... a dominant negative phenotype.

@en

prefLabel

Deletion of the carboxyl-termi ...... a dominant negative phenotype.

@ast

Deletion of the carboxyl-termi ...... a dominant negative phenotype.

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P1433

Molecular and Cellular Biology

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Deletion of the carboxyl-termi ...... a dominant negative phenotype

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P2093

A Sotiropoulos

http://www.w3.org/2001/XMLSchema#string

B Groner

http://www.w3.org/2001/XMLSchema#string

C Gartmann

http://www.w3.org/2001/XMLSchema#string

F Gouilleux

http://www.w3.org/2001/XMLSchema#string

R Jähne

http://www.w3.org/2001/XMLSchema#string

S Berchtold

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V Gouilleux-Gruart

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X Liu

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P2860

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

Regulation of mammary gland factor/Stat5a during mammary gland development

Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15

Requirement of serine phosphorylation for formation of STAT-promoter complexes

Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process

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5691-5700

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10.1128/MCB.16.10.5691

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10

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P478

16

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P50

Richard Moriggl

Lothar Hennighausen

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1996-10-01T00:00:00Z

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P698

8816482

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P932

231569

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