Mitochondria in amyotrophic lateral sclerosis: a trigger and a target. - Wikidata - awgldk - TriplyDB

Mitochondria in amyotrophic lateral sclerosis: a trigger and a target.

Mitochondria in amyotrophic lateral sclerosis: a trigger and a target.

http://www.wikidata.org/entity/Q36565597

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Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation Sperm and oocyte communication mechanisms controlling C. elegans fertility Insulin-like growth factor-I for the treatment of amyotrophic lateral sclerosis A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice MicroRNA-206: a potential circulating biomarker candidate for amyotrophic lateral sclerosis Skeletal Muscle Satellite Cells, Mitochondria, and MicroRNAs: Their Involvement in the Pathogenesis of ALS Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration.Axonal mitochondrial clusters containing mutant SOD1 in transgenic models of ALS.Vascular endothelial growth factor prevents G93A-SOD1-induced motor neuron degeneration.Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand?Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis.Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study.Oxidative stress biomarkers in sporadic ALS Seeking homeostasis: temporal trends in respiration, oxidation, and calcium in SOD1 G93A Amyotrophic Lateral Sclerosis mice.Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors.Cancer as a mitochondrial metabolic disease.Zinc regulates the stability of repetitive minisatellite DNA tracts during stationary phase.Amyotrophic lateral sclerosis: all roads lead to Rome.Skeletal muscle in motor neuron diseases: therapeutic target and delivery route for potential treatments.Dynein disruption perturbs post-synaptic components and contributes to impaired MuSK clustering at the NMJ: implication in ALS.Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons.Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants.Mitochondria: a therapeutic target in neurodegeneration Mitochondrial medicine for neurodegenerative diseases.State of the art and the dark side of amyotrophic lateral sclerosis.Energy Homeostasis and Abnormal RNA Metabolism in Amyotrophic Lateral Sclerosis Experimental models for the study of neurodegeneration in amyotrophic lateral sclerosis.Cerebrospinal Fluid from Sporadic Amyotrophic Lateral Sclerosis Patients Induces Mitochondrial and Lysosomal Dysfunction.Cellular Signature of SIL1 Depletion: Disease Pathogenesis due to Alterations in Protein Composition Beyond the ER Machinery.Early ALS-type gait abnormalities in AMP-dependent protein kinase-deficient mice suggest a role for this metabolic sensor in early stages of the disease.Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein.Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency.Analysis of European case-control studies suggests that common inherited variation in mitochondrial DNA is not involved in susceptibility to amyotrophic lateral sclerosis.Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis.Altered in vitro proliferation of mouse SOD1-G93A skeletal muscle satellite cells.Mutation Screening of the CHCHD10 Gene in Chinese Patients with Amyotrophic Lateral Sclerosis.Mitochondrial perturbance and execution of apoptosis in platelet mitochondria of patients with amyotrophic lateral sclerosis.Energy metabolism in ALS: an underappreciated opportunity?Micro-computed tomography for non-invasive evaluation of muscle atrophy in mouse models of disease.

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P2860

Mitochondria in amyotrophic lateral sclerosis: a trigger and a target.

http://www.wikidata.org/entity/Q36565597

description

2004 nî lūn-bûn

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Mitochondria in amyotrophic lateral sclerosis: a trigger and a target.

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Mitochondria in amyotrophic lateral sclerosis: a trigger and a target.

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Mitochondria in amyotrophic lateral sclerosis: a trigger and a target.

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Neurodegenerative Diseases

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Mitochondria in amyotrophic lateral sclerosis: a trigger and a target.

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Hugues Oudart

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Jean-Philippe Loeffler

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Jose-Luis Gonzalez de Aguilar

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Luc Dupuis

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Luis Barbeito

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Marc de Tapia

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P2860

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4)

ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor

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10.1159/000085063

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6

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1

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amyotrophic lateral sclerosis