A conformational switch in nuclear hormone receptors is involved in coupling hormone binding to corepressor release
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Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemiaAlien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamilyThe structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12Defining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor Ligand Binding DomainComponents of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6The SMRT corepressor is a target of phosphorylation by protein kinase CK2 (casein kinase II)Thyroid hormone receptors mutated in liver cancer function as distorted antimorphsThyroid hormone stimulates acetyl-coA carboxylase-alpha transcription in hepatocytes by modulating the composition of nuclear receptor complexes bound to a thyroid hormone response element.Transcriptional silencing is defined by isoform- and heterodimer-specific interactions between nuclear hormone receptors and corepressorsIdentification of the Sin3-binding site in Ume6 defines a two-step process for conversion of Ume6 from a transcriptional repressor to an activator in yeast.The interaction between nuclear receptor corepressor and histone deacetylase 3 regulates both positive and negative thyroid hormone action in vivo.Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression.Mutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with two renal clear cell carcinomas.Research resource: identification of novel coregulators specific for thyroid hormone receptor-β2.Aspects on pathophysiological mechanisms in COPD.Transcriptional anti-repression. Thyroid hormone receptor beta-2 recruits SMRT corepressor but interferes with subsequent assembly of a functional corepressor complex.Retinoid isomers differ in the ability to induce release of SMRT corepressor from retinoic acid receptor-alphaThe p160 coactivator PAS-B motif stabilizes nuclear receptor binding and contributes to isoform-specific regulation by thyroid hormone receptors.Direct interdomain interactions can mediate allosterism in the thyroid receptorVitamin D-dependent recruitment of corepressors to vitamin D/retinoid X receptor heterodimersA novel role for helix 12 of retinoid X receptor in regulating repression.Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1.A dominant negative PPARgamma mutant shows altered cofactor recruitment and inhibits adipogenesis in 3T3-L1 cells.Transcriptional repression by thyroid hormone receptors. A role for receptor homodimers in the recruitment of SMRT corepressor.Signaling by tyrosine kinases negatively regulates the interaction between transcription factors and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor.Molecular determinants of the balance between co-repressor and co-activator recruitment to the retinoic acid receptor.Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.Mechanisms of the mouse orphan nuclear receptor TR2-11-mediated gene suppression.Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling.
P2860
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P2860
A conformational switch in nuclear hormone receptors is involved in coupling hormone binding to corepressor release
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
A conformational switch in nuc ...... binding to corepressor release
@ast
A conformational switch in nuc ...... binding to corepressor release
@en
type
label
A conformational switch in nuc ...... binding to corepressor release
@ast
A conformational switch in nuc ...... binding to corepressor release
@en
prefLabel
A conformational switch in nuc ...... binding to corepressor release
@ast
A conformational switch in nuc ...... binding to corepressor release
@en
P2093
P2860
P356
P1476
A conformational switch in nuc ...... binding to corepressor release
@en
P2093
P2860
P304
P356
10.1128/MCB.17.10.6131
P407
P577
1997-10-01T00:00:00Z