Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling. - Wikidata - awgldk - TriplyDB

Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling.

Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling.

http://www.wikidata.org/entity/Q36638911

about

Cloning and characterization of CIS 1b (cytokine inducible SH2-containing protein 1b), an alternative splicing form of CIS 1 gene The role of microtubule-associated protein 1S in SOCS3 regulation of IL-6 signaling The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation The role of suppressors of cytokine signalling in human neoplasms Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130 Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo Pim serine/threonine kinases regulate the stability of Socs-1 protein TYK2 kinase activity is required for functional type I interferon responses in vivo Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus.Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3.Intracellular delivery of a cell-penetrating SOCS1 that targets IFN-gamma signaling.Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor JAK-STAT signaling activated by Abl oncogenes.SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation.IL-6 transgenic mouse model for extraosseous plasmacytoma.Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency.Janus kinases: components of multiple signaling pathways.IL-4 signaling is regulated through the recruitment of phosphatases, kinases, and SOCS proteins to the receptor complex.Satellite cells derived from obese humans with type 2 diabetes and differentiated into myocytes in vitro exhibit abnormal response to IL-6.Suppressors of cytokine signalling: SOCS.Regulation of cytokine receptor signaling by SOCS1.The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2 Are SOCS suppressors, regulators, and degraders?Extrinsic and intrinsic determinants of nerve regeneration Global transcriptional analysis delineates the differential inflammatory response interleukin-15 elicits from cultured human T cells Role of the HIV-1 Matrix Protein in Gag Intracellular Trafficking and Targeting to the Plasma Membrane for Virus Assembly.

P2860

Q22254635-FF5FBDAC-1E56-4B3D-A206-589B563D28A2 Q24316883-87B42690-9CF1-4A2D-83A6-7F3D23C57A54 Q24321847-36D739B2-7405-4998-841A-9327BBA817A1 Q24529081-028FC5C7-0BEE-4F62-9036-C30E9B1D19AC Q24532238-A4CD617D-E1FF-4E1D-B129-03220BBE6455 Q24537294-6EED7127-4188-43CE-887E-DDCB62A4E9AC Q24564225-5DF3D6E0-217C-418A-90B1-E7D026D2EE2F Q24648112-F4195BDC-B0BE-4FAB-A312-F8CBECDB924C Q24654107-351BF1E2-BD6C-4E89-AC61-A2DD5F203CE1 Q24675835-B2A42F26-1EB1-43E7-A8CB-E234206BD76D Q27026783-A588FD5D-BD73-422C-9B40-3ADF573E6F83 Q27649020-CE09FAAB-800E-410E-946A-8096DEA05C2C Q28139486-63CE400A-AD51-48AA-8A0B-936D2C89F79C Q28142615-CFCB9FFD-44F4-40FF-8D58-D71D85388F76 Q28187852-CA9696AF-B164-4E5E-ABE9-D4A543E02780 Q28211408-CD4AAF76-8C79-45BA-8739-04D079C7F86A Q28586863-F2477797-EAAB-43B7-9635-3F2564EF4FEE Q28588059-909F7A51-ADD6-4B96-A0AC-5F7BDC33DCFB Q28594323-244F5083-97E7-44A5-A15D-0234049706D4 Q28728338-397D48A8-A77B-457B-BCB6-DEA66C3EC688 Q33383235-33DF1D5F-EE2E-4A36-9365-2E379AEC2A82 Q33496779-9B4621DF-28E9-4682-BC66-565DD15D24A3 Q33547349-E009A3CB-3A2B-4D53-9F55-B224362C46D7 Q33560131-A8B37585-272C-4520-9C39-321270271BFC Q33901975-F189F187-0C6A-408F-8854-6D23FF3079BC Q33941370-877F80F2-FF39-4AAF-AB0A-EABE4C517999 Q33958723-BB8517F9-9BFF-4BC0-AE42-09607475E973 Q34009997-814A26A2-8FDB-4233-90DD-1D1D668CE12A Q34098712-8FBDC165-34CF-4598-8709-4C86DE07A3E3 Q34103659-02BE3A57-1DFD-44DD-A82F-81415B9DAF24 Q34170862-10771D58-2D2D-46DE-BB9F-58FFFD0DEA3A Q34326387-83AAA96C-8CF8-4685-846A-159333BD6BC9 Q35088551-9329816C-4794-4FC6-87BD-84965B0B12AA Q35096707-ABAE8DF6-DBE0-46E2-807F-42BB17204004 Q35211894-CC85ABB8-94C8-4CC3-B860-D75291F075FE Q35311132-1ABE15DB-7AE0-47EA-91CD-BA04069FD89B Q35615629-AD27AF51-EFC0-4B47-A29E-1F56D7E6EE17 Q35654115-085DBDEC-29A0-441E-B678-E9C173319D9A Q35758126-4077ACF1-F2D6-4884-BFE0-4ADD4E538DA9 Q35761675-07DDC065-A533-4276-839B-396C173D8588

P2860

Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling.

http://www.wikidata.org/entity/Q36638911

description

1998 nî lūn-bûn

@nan

1998年の論文

@ja

1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

1998年论文

@zh

1998年论文

@zh-cn

name

Three distinct domains of SSI- ...... on of interleukin 6 signaling.

@ast

Three distinct domains of SSI- ...... on of interleukin 6 signaling.

@en

type

label

Three distinct domains of SSI- ...... on of interleukin 6 signaling.

@ast

Three distinct domains of SSI- ...... on of interleukin 6 signaling.

@en

prefLabel

Three distinct domains of SSI- ...... on of interleukin 6 signaling.

@ast

Three distinct domains of SSI- ...... on of interleukin 6 signaling.

@en

P1433

Q36638911-782FF3C3-053D-416E-A16E-00901FBE9816

P1476

Q36638911-BCCCB164-B9FC-4357-9824-924CAA558C29

P2093

Q36638911-1002CE64-0AC6-43C4-8AFA-4F164586ED3F

Q36638911-208ED4AF-6725-4692-B94B-57219DA3AB5D

Q36638911-2AE5E292-C878-44ED-AADE-50038CB9B660

Q36638911-2F205C46-737E-497B-AB21-0E2E24E4BADB

Q36638911-5F8A3F7E-BDAD-492B-815A-4B57F6112941

Q36638911-928B0A42-1503-436E-A766-58717D85D225

Q36638911-B9DB5EB0-87D9-4071-854F-9D8D90CB3FC6

Q36638911-D54DD84C-8CF2-4CB2-93CD-077D55510CEA

Q36638911-D83B5CCB-3E57-4844-B188-20C37F53A29A

P2860

Q36638911-096FB3D3-4594-485E-B56E-6C2919E16C21

Q36638911-12A5819B-DD30-4617-AB89-6280D039398C

Q36638911-12DA2BEB-49BD-4C8B-B4C1-1049034AAAD1

Q36638911-2069815E-0B98-46E7-B4CF-2DE87E7B0693

Q36638911-2B5AA2BD-24F1-4985-A461-D4706D297401

Q36638911-495AB41A-A404-46A1-9B90-97A78ABE73A9

Q36638911-4A92CA94-0FD6-4F14-960A-6FCDE75361D9

Q36638911-671FDECA-EDEE-4CAF-8619-59274D5779B1

Q36638911-67FF2B56-98A0-40CA-8D95-D6B32C74042C

Q36638911-94A3CA90-9C51-46C4-B1F4-1E0B1A46A44B

P304

Q36638911-4392ED6A-8760-4A18-8497-75BFEE0FF1DC

P31

Q36638911-65A69035-FCFF-41E2-88A0-34A26384D43D

P356

Q36638911-DFFE9410-6672-4FE0-9E2D-EBA3E93D5DCE

P407

Q36638911-9F3E12F4-DC8B-4087-9478-186A5BF72DB5

P433

Q36638911-F0DE10C7-B33E-499D-867A-F1026F3F7168

P478

Q36638911-2E91DEA7-5CF3-4BF6-8378-CCDEAECBADAB

P577

Q36638911-1922ECE3-6B92-49EB-A35A-33213067992B

P5875

Q36638911-7BA2A692-3268-4B99-9510-523E3095D26E

P698

Q36638911-F492A405-F5CC-4619-8002-404A3B8CBF35

P932

Q36638911-145B7AC4-95A3-404A-A7CE-C73F32824ECB

P356

PNAS.95.22.13130

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Three distinct domains of SSI- ...... on of interleukin 6 signaling.

@en

P2093

H Saito

http://www.w3.org/2001/XMLSchema#string

K Yoshizaki

http://www.w3.org/2001/XMLSchema#string

M Fujimoto

http://www.w3.org/2001/XMLSchema#string

M Narazaki

http://www.w3.org/2001/XMLSchema#string

T Kajita

http://www.w3.org/2001/XMLSchema#string

T Kishimoto

http://www.w3.org/2001/XMLSchema#string

T Matsumoto

http://www.w3.org/2001/XMLSchema#string

T Naka

http://www.w3.org/2001/XMLSchema#string

Y Morita

http://www.w3.org/2001/XMLSchema#string

P2860

A family of cytokine-inducible inhibitors of signalling

A new protein containing an SH2 domain that inhibits JAK kinases

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

Twenty proteins containing a C-terminal SOCS box form five structural classes

Cloning and characterization of novel CIS family genes

Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation

P304

13130-13134

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.95.22.13130

http://www.w3.org/2001/XMLSchema#string

P407

P433

22

http://www.w3.org/2001/XMLSchema#string

P478

95

http://www.w3.org/2001/XMLSchema#string

P577

1998-10-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

242906960

http://www.w3.org/2001/XMLSchema#string

P698

9789053

http://www.w3.org/2001/XMLSchema#string

P932

23734

http://www.w3.org/2001/XMLSchema#string