A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2.
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Proteasome-independent disruption of PML oncogenic domains (PODs), but not covalent modification by SUMO-1, is required for human cytomegalovirus immediate-early protein IE1 to inhibit PML-mediated transcriptional repression.An HIV feedback resistor: auto-regulatory circuit deactivator and noise bufferProlonged activation of NF-kappaB by human cytomegalovirus promotes efficient viral replication and late gene expressionHuman cytomegalovirus and human herpesvirus 6 genes that transform and transactivateActivation of transcription of the human cytomegalovirus early UL4 promoter by the Ets transcription factor binding element.Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PMLDefective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant.Identification of positive and negative regulatory regions involved in regulating expression of the human cytomegalovirus UL94 late promoter: role of IE2-86 and cellular p53 in mediating negative regulatory function.A cis repression sequence adjacent to the transcription start site of the human cytomegalovirus US3 gene is required to down regulate gene expression at early and late times after infectionIn vivo replication of recombinant murine cytomegalovirus driven by the paralogous major immediate-early promoter-enhancer of human cytomegalovirusA strong negative transcriptional regulatory region between the human cytomegalovirus UL127 gene and the major immediate-early enhancer.Identification of a novel element involved in regulation of the lytic switch BZLF1 gene promoter of Epstein-Barr virusEvaluation of interactions of human cytomegalovirus immediate-early IE2 regulatory protein with small ubiquitin-like modifiers and their conjugation enzyme Ubc9Antagonistic determinants controlling replicative and latent states of human cytomegalovirus infectionTwo Sp1/Sp3 binding sites in the major immediate-early proximal enhancer of human cytomegalovirus have a significant role in viral replication.Functional properties of the human cytomegalovirus IE86 protein required for transcriptional regulation and virus replicationNegative regulation of the adeno-associated virus (AAV) P5 promoter involves both the P5 rep binding site and the consensus ATP-binding motif of the AAV Rep68 proteinRole of regulatory elements and the MAPK/ERK or p38 MAPK pathways for activation of human cytomegalovirus gene expression.A recombinant rhesus cytomegalovirus expressing enhanced green fluorescent protein retains the wild-type phenotype and pathogenicity in fetal macaques.Alternative splicing of the human cytomegalovirus major immediate-early genes affects infectious-virus replication and control of cellular cyclin-dependent kinase.Inhibition of cellular DNA synthesis by the human cytomegalovirus IE86 protein is necessary for efficient virus replication.The human cytomegalovirus major immediate-early enhancer determines the efficiency of immediate-early gene transcription and viral replication in permissive cells at low multiplicity of infection.Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vectorCytomegalovirus immediate early genes prevent the inhibitory effect of cyclosporin A on interleukin 2 gene transcription.The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus.Isolation and characterization of a low-abundance splice variant from the human cytomegalovirus major immediate-early gene region.Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters.The late promoter of the human cytomegalovirus viral DNA polymerase processivity factor has an impact on delayed early and late viral gene products but not on viral DNA synthesisThe autoregulatory and transactivating functions of the human cytomegalovirus IE86 protein use independent mechanisms for promoter binding.Cellular or viral protein binding to a cytomegalovirus promoter transcription initiation site: effects on transcription.Two distinct upstream regulatory domains containing multicopy cellular transcription factor binding sites provide basal repression and inducible enhancer characteristics to the immediate-early IES (US3) promoter from human cytomegalovirusThe IE2 regulatory protein of human cytomegalovirus induces expression of the human transforming growth factor beta1 gene through an Egr-1 binding site.The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter.Characterization of the human cytomegalovirus irs1 and trs1 genes: a second immediate-early transcription unit within irs1 whose product antagonizes transcriptional activation.The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells.Human cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint function.An in vitro system for human cytomegalovirus immediate early 2 protein (IE2)-mediated site-dependent repression of transcription and direct binding of IE2 to the major immediate early promoter.Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression.Human cytomegalovirus immediate early interaction with host nuclear structures: definition of an immediate transcript environment.A cis element between the TATA Box and the transcription start site of the major immediate-early promoter of human cytomegalovirus determines efficiency of viral replication.
P2860
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P2860
A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
A cis-acting element in the ma ...... or negative regulation by IE2.
@ast
A cis-acting element in the ma ...... or negative regulation by IE2.
@en
type
label
A cis-acting element in the ma ...... or negative regulation by IE2.
@ast
A cis-acting element in the ma ...... or negative regulation by IE2.
@en
prefLabel
A cis-acting element in the ma ...... or negative regulation by IE2.
@ast
A cis-acting element in the ma ...... or negative regulation by IE2.
@en
P2093
P2860
P1433
P1476
A cis-acting element in the ma ...... for negative regulation by IE2
@en
P2093
P2860
P304
P407
P577
1991-02-01T00:00:00Z