Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis
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The conserved 5'-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivoSpi-1/PU.1 is a positive regulator of the Fli-1 gene involved in inhibition of erythroid differentiation in friend erythroleukemic cell linesDirect interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cellsNegative cross-talk between hematopoietic regulators: GATA proteins repress PU.1Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytesSpi-B can functionally replace PU.1 in myeloid but not lymphoid developmentCloning and functional analysis of the mouse 5-lipoxygenase promoter.Functional imaging of interleukin 1 beta expression in inflammatory process using bioluminescence imaging in transgenic miceThe mouse and human Fli1 genes are similarly regulated by Ets factors in T cells.Potential autoregulation of transcription factor PU.1 by an upstream regulatory elementNormal myeloid development requires both the glutamine-rich transactivation domain and the PEST region of transcription factor PU.1 but not the potent acidic transactivation domain.TC21 and Ras share indistinguishable transforming and differentiating activities.Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B.C/EBPbeta (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts.Expression and function of Ets transcription factors in mammalian development: a regulatory network.Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE).A residue of the ETS domain mutated in the v-ets oncogene is essential for the DNA-binding and transactivating properties of the ETS-1 and ETS-2 proteins.Distinct mechanisms for induction and tolerance regulate the immediate early genes encoding interleukin 1β and tumor necrosis factor α.A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74.Do lampreys have lymphocytes? The Spi evidence.Reprogramming leukemia cells to terminal differentiation and growth arrest by RNA interference of PU.1.PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer.Inhibition of hematopoiesis by competitive binding of transcription factor PU.1.Transgenic expression of Spi-C impairs B-cell development and function by affecting genes associated with BCR signaling.Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1.Epstein-Barr virus nuclear protein 3C modulates transcription through interaction with the sequence-specific DNA-binding protein J kappaThe murine AIDS defective provirus acts as an insertional mutagen in its infected target B cellsTargeted disruption of the PU.1 gene results in multiple hematopoietic abnormalitiesRestriction of interferon gamma responsiveness and basal expression of the myeloid human Fc gamma R1b gene is mediated by a functional PU.1 site and a transcription initiator consensusThe Ets protein Spi-B is expressed exclusively in B cells and T cells during development.Molecular mechanism of allergy-related gene regulation and hematopoietic cell development by transcription factors.An upstream control region required for inducible transcription of the mouse H1(zero) histone gene during terminal differentiationInhibition of IL-1beta transcription by peptides derived from the hCMV IE2 transactivator.A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1.The Ets-related transcription factor PU.1 immortalizes erythroblastsStructurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia.Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages.Spi-1 and Fli-1 directly activate common target genes involved in ribosome biogenesis in Friend erythroleukemic cells.Phosphorylation of IRF8 in a pre-associated complex with Spi-1/PU.1 and non-phosphorylated Stat1 is critical for LPS induction of the IL1B geneThe nfkb1 promoter is controlled by proteins of the Ets family.
P2860
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P2860
Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Mouse beta-globin DNA-binding ...... topoietic cells and the testis
@ast
Mouse beta-globin DNA-binding ...... topoietic cells and the testis
@en
type
label
Mouse beta-globin DNA-binding ...... topoietic cells and the testis
@ast
Mouse beta-globin DNA-binding ...... topoietic cells and the testis
@en
prefLabel
Mouse beta-globin DNA-binding ...... topoietic cells and the testis
@ast
Mouse beta-globin DNA-binding ...... topoietic cells and the testis
@en
P2093
P2860
P356
P1476
Mouse beta-globin DNA-binding ...... topoietic cells and the testis
@en
P2093
A D D'Andrea
D E Housman
D L Galson
J O Hensold
M Schalling
T R Bishop
P2860
P304
P356
10.1128/MCB.13.5.2929
P407
P577
1993-05-01T00:00:00Z