Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.
about
Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcriptionSynergistic activation of the human orphan nuclear receptor SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin geneDiabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient miceMolecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domainIdentification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcriptionNeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene familyIdentification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factorsNeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system.Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1.The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix proteinThe bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreasThe MafA transcription factor appears to be responsible for tissue-specific expression of insulinBasic helix-loop-helix transcription factors and enteroendocrine cell differentiationNeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin geneThe basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, TwistHormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1Phosphorylation of E47 as a potential determinant of B-cell-specific activityPurification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cellsFoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start siteStimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2Hypoxic preconditioning differentially affects GABAergic and glutamatergic neuronal cells in the injured cerebellum of the neonatal ratGenetics and pathophysiology of neonatal diabetes mellitus.Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoterCyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroDDifferential interactions of Id proteins with basic-helix-loop-helix transcription factorsTarget-dependent effect of phosphorylation on the DNA binding activity of the TAL1/SCL oncoproteinThe Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcriptionNeurogenin and NeuroD direct transcriptional targets and their regulatory enhancersGenetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cellsTranscriptional regulation of mouse type 1 inositol 1,4,5-trisphosphate receptor gene by NeuroD-related factorNeuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretionMembers of the large Maf transcription family regulate insulin gene transcription in islet beta cellsLoss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsyThe basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cellsGlucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localizationDeregulation of CREB signaling pathway induced by chronic hyperglycemia downregulates NeuroD transcriptionPOU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element
P2860
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P2860
Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Tissue-specific regulation of ...... op-helix transcription factor.
@ast
Tissue-specific regulation of ...... op-helix transcription factor.
@en
type
label
Tissue-specific regulation of ...... op-helix transcription factor.
@ast
Tissue-specific regulation of ...... op-helix transcription factor.
@en
prefLabel
Tissue-specific regulation of ...... op-helix transcription factor.
@ast
Tissue-specific regulation of ...... op-helix transcription factor.
@en
P2093
P356
P1433
P1476
Tissue-specific regulation of ...... op-helix transcription factor.
@en
P2093
P304
P356
10.1101/GAD.9.8.1009
P577
1995-04-01T00:00:00Z