Btk dosage determines sensitivity to B cell antigen receptor cross-linking
about
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancyThe proline rich region of the Tec homology domain of ITK regulates its activityPKCbeta modulates antigen receptor signaling via regulation of Btk membrane localizationItk phosphorylation sites are required for functional activity in primary T cells.In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies.Development of B-lineage predominant lentiviral vectors for use in genetic therapies for B cell disordersA balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling.A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation.B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levelsPhosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytesPosttranscriptional regulation of Bruton's tyrosine kinase expression in antigen receptor-stimulated splenic B cells.The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production.The effect of food on the pharmacokinetics of oral ibrutinib in healthy participants and patients with chronic lymphocytic leukemia.Targeting B cells for the treatment of rheumatoid arthritisA sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.Genetic analysis of patients with defects in early B-cell development.Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.MicroRNAs prevent the generation of autoreactive antibodies.Receptor crosstalk: reprogramming B cell receptor signalling to an alternate pathway results in expression and secretion of the autoimmunity-associated cytokine, osteopontinMediation of transitional B cell maturation in the absence of functional Bruton's tyrosine kinase.Mechanisms underlying in vivo polysaccharide-specific immunoglobulin responses to intact extracellular bacteria.Bruton tyrosine kinase (BTK) and its role in B-cell malignancy.Tyrosine kinase inhibitors as potential drugs for B-cell lymphoid malignancies and autoimmune disorders.Agammaglobulinemia: causative mutations and their implications for novel therapies.BAFF receptor and TACI in B-1b cell maintenance and antibacterial responses.Thymocyte selection in Vav and IRF-1 gene-deficient mice.BTK Signaling in B Cell Differentiation and Autoimmunity.The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy.Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibitionEnhanced Bruton's Tyrosine Kinase Activity in Peripheral Blood B Lymphocytes From Patients With Autoimmune Disease.A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease.Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families.Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk.Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.Role of B cell receptor signaling in IL-10 production by normal and malignant B-1 cells.Induction of in vivo antipolysaccharide immunoglobulin responses to intact Streptococcus pneumoniae is more heavily dependent on Btk-mediated B-cell receptor signaling than antiprotein responses.Btk regulates multiple stages in the development and survival of B-1 cells.
P2860
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P2860
Btk dosage determines sensitivity to B cell antigen receptor cross-linking
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Btk dosage determines sensitivity to B cell antigen receptor cross-linking
@ast
Btk dosage determines sensitivity to B cell antigen receptor cross-linking
@en
type
label
Btk dosage determines sensitivity to B cell antigen receptor cross-linking
@ast
Btk dosage determines sensitivity to B cell antigen receptor cross-linking
@en
prefLabel
Btk dosage determines sensitivity to B cell antigen receptor cross-linking
@ast
Btk dosage determines sensitivity to B cell antigen receptor cross-linking
@en
P2093
P2860
P356
P1476
Btk dosage determines sensitivity to B cell antigen receptor cross-linking
@en
P2093
A B Satterthwaite
H Cheroutre
P2860
P304
13152-13157
P356
10.1073/PNAS.94.24.13152
P407
P577
1997-11-01T00:00:00Z