Overexpression of Separase induces aneuploidy and mammary tumorigenesis. - Wikidata - awgldk - TriplyDB

Overexpression of Separase induces aneuploidy and mammary tumorigenesis.

Overexpression of Separase induces aneuploidy and mammary tumorigenesis.

http://www.wikidata.org/entity/Q36861774

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Cornelia de Lange syndrome, cohesin, and beyond Chromosomal instability and cancer: a complex relationship with therapeutic potential Transcriptional control of mitosis: deregulation and cancer Cohesin: functions beyond sister chromatid cohesion Increased RPA1 gene dosage affects genomic stability potentially contributing to 17p13.3 duplication syndrome Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice The mitotic origin of chromosomal instability.Critical differences between isoforms of securin reveal mechanisms of separase regulation Identifying common prognostic factors in genomic cancer studies: a novel index for censored outcomes.MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERα)-positive mammary adenocarcinomas.Targeted sister chromatid cohesion by Sir2.One-hit wonders of genomic instability.Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme Synthetic lethality of cohesins with PARPs and replication fork mediators.Genetic heterogeneity in Cornelia de Lange syndrome (CdLS) and CdLS-like phenotypes with observed and predicted levels of mosaicism.Cancer chromosomal instability: therapeutic and diagnostic challenges.The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase.Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy.Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation.Chromosomal instability as a prognostic marker in cervical cancer.Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma.Measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains.Targeting karyotypic complexity and chromosomal instability of cancer cells.Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2.Mutational inactivation of STAG2 causes aneuploidy in human cancer c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia Structural basis of cohesin cleavage by separase.Oncogenic activity of separase.Mechanisms of chromosomal instability.Integrative analysis of mutational and transcriptional profiles reveals driver mutations of metastatic breast cancers.Development and validation of a fluorogenic assay to measure separase enzyme activity.Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos.Translocations in epithelial cancers.Road to the crossroads of life and death: linking sister chromatid cohesion and separation to aneuploidy, apoptosis and cancer.Multi-layered cancer chromosomal instability phenotype.Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis New insights into the troubles of aneuploidy

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Overexpression of Separase induces aneuploidy and mammary tumorigenesis.

http://www.wikidata.org/entity/Q36861774

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Overexpression of Separase induces aneuploidy and mammary tumorigenesis.

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Overexpression of Separase induces aneuploidy and mammary tumorigenesis.

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Overexpression of Separase induces aneuploidy and mammary tumorigenesis.

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PNAS.0801610105

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Overexpression of Separase induces aneuploidy and mammary tumorigenesis.

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Adel K El-Naggar

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Daniel Medina

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Debananda Pati

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Dipanjan Basu

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Frances S Kittrell

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Gouquing Ge

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Nenggang Zhang

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Pulivarthi H Rao

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Rene Meyer

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Subhashree Pradhan

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P2860

Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

Regulation of human separase by securin binding and autocleavage

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells

The links between axin and carcinogenesis

The epithelial-mesenchymal transition: new insights in signaling, development, and disease

Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24

Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression

Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p

Whose end is destruction: cell division and the anaphase-promoting complex

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13033-13038

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35

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105

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23194890

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18728194

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