Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase
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Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal StructuresX-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide HydrolaseFluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide HydrolaseReversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting AnalgesicsRational Design of Fatty Acid Amide Hydrolase Inhibitors That Act by Covalently Bonding to Two Active Site ResiduesPreclinical Characterization of the FAAH Inhibitor JNJ-42165279Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disordersApproximating protein flexibility through dynamic pharmacophore models: application to fatty acid amide hydrolase (FAAH)α-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain.The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Discovery libraries targeting the major enzyme classes: the serine hydrolases.Sulfonyl fluoride inhibitors of fatty acid amide hydrolase.Interferometric methods for label-free molecular interaction studiesRefined homology model of monoacylglycerol lipase: toward a selective inhibitor.α-Ketoheterocycle-based Inhibitors of Fatty Acid Amide Hydrolase (FAAH).Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolaseOptimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activitySynthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.Design, synthesis, and characterization of α-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolaseFatty acid amide signaling molecules.Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate.Label-free quantification of membrane-ligand interactions using backscattering interferometry.Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.Merging gold catalysis, organocatalytic oxidation, and Lewis acid catalysis for chemodivergent synthesis of functionalized oxazoles from N-propargylamides.
P2860
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P2860
Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Potent and selective alpha-ket ...... me, fatty acid amide hydrolase
@en
type
label
Potent and selective alpha-ket ...... me, fatty acid amide hydrolase
@en
prefLabel
Potent and selective alpha-ket ...... me, fatty acid amide hydrolase
@en
P2093
P2860
P921
P356
P1476
Potent and selective alpha-ket ...... me, fatty acid amide hydrolase
@en
P2093
Dale L Boger
Donmienne Leung
F Anthony Romero
F Scott Kimball
Heather S Hoover
Inkyu Hwang
J Guy Breitenbucher
Thomas J Rayl
P2860
P304
P356
10.1021/JM0611509
P407
P577
2007-02-06T00:00:00Z