Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.
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Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal StructuresX-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide HydrolaseFluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide HydrolaseReversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting AnalgesicsRational Design of Fatty Acid Amide Hydrolase Inhibitors That Act by Covalently Bonding to Two Active Site Residuesα-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain.The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Discovery libraries targeting the major enzyme classes: the serine hydrolases.α-Ketoheterocycle-based Inhibitors of Fatty Acid Amide Hydrolase (FAAH).Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α InhibitorsDesign, synthesis, and characterization of α-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolaseFatty acid amide signaling molecules.Lipolytic proteomics.Recent advances in the discovery and evaluation of fatty acid amide hydrolase inhibitors.Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain.The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.Reaction of 2-Aryl-4-Cyano-1,3-Oxazole-5-Sulfonyl Chlorides With 5-Amino-1H-Pyrazoles and 5-Amino-1H-1,2,4-Triazole
P2860
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P2860
Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Exploration of a fundamental s ...... of fatty acid amide hydrolase.
@en
type
label
Exploration of a fundamental s ...... of fatty acid amide hydrolase.
@en
prefLabel
Exploration of a fundamental s ...... of fatty acid amide hydrolase.
@en
P2093
P2860
P1476
Exploration of a fundamental s ...... of fatty acid amide hydrolase.
@en
P2093
Dale L Boger
Dustin G Hochstatter
Jessica K DeMartino
Joie Garfunkle
P2860
P304
P356
10.1016/J.BMCL.2008.06.084
P407
P577
2008-06-28T00:00:00Z