Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastine
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Evaluation of Biosynthetic Pathway and Engineered Biosynthesis of AlkaloidsTotal synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function propertiesTotal synthesis of (+)-fendleridine (aspidoalbidine) and (+)-1-acetylaspidoalbidineAsymmetric total synthesis of vindolineTotal synthesis and evaluation of a key series of C5-substituted vinblastine derivativesAsymmetric total synthesis of vindorosine, vindoline, and key vinblastine analoguesCatharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues.Cycloadditions of noncomplementary substituted 1,2,3-triazines.Fe(III)/NaBH4-mediated free radical hydrofluorination of unactivated alkenesDe novo production of the plant-derived alkaloid strictosidine in yeastInverse electron demand Diels-Alder reactions of 1,2,3-triazines: pronounced substituent effects on reactivity and cycloaddition scopeHigh content screening of diverse compound libraries identifies potent modulators of tubulin dynamics.10'-Fluorovinblastine and 10'-Fluorovincristine: Synthesis of a Key Series of Modified Vinca Alkaloids.Total synthesis of (-)-kopsinine and ent-(+)-kopsinineIron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analoguesDivergent total syntheses of (-)-aspidospermine and (+)-spegazzinine.Cycloadditions of 1,2,3-Triazines Bearing C5-Electron Donating Substituents: Robust Pyrimidine SynthesisExamining the transcriptional response of overexpressing anthranilate synthase in the hairy roots of an important medicinal plant Catharanthus roseus by RNA-seq.Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.New insights into the mechanism and an expanded scope of the Fe(III)-mediated vinblastine coupling reaction.Total Synthesis of (-)-Vindoline and (+)-4-epi-Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4 + 2]/[3 + 2] Cycloaddition Cascade Initiated by an Allene Dienophile.Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: core redesign.Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications.A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20' urea derivatives.Total synthesis of kopsinine.Hypervalent iodine(III)-promoted intermolecular C-C coupling of vindoline with β-ketoesters and related substrates.Study on the total synthesis of velbanamine: Chemoselective dioxygenation of alkenes with PIFA via a stop-and-flow strategyUltrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface.Potent Vinblastine C20' Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line.Total synthesis of vinblastine, vincristine, related natural products, and key structural analoguesSynthesis and structure of 1-(2-bromo-phen-yl)-2-chloro-3-(2-chloracet-yl)-1H-indoleAllenyl azide cycloaddition chemistry. 2,3-cyclopentennelated indole synthesis through indolidene intermediatesFolivory elicits a strong defense reaction in Catharanthus roseus: metabolomic and transcriptomic analyses reveal distinct local and systemic responses.Transannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues.Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity.Total syntheses of (-)-kopsifoline D and (-)-deoxoapodine: divergent total synthesis via late-stage key strategic bond formation.Gas extrusion in natural products total synthesis.Transition metal-promoted biomimetic steps in total syntheses.Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins.
P2860
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P2860
Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastine
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Direct coupling of catharanthi ...... f (+)- and ent-(-)-vinblastine
@en
type
label
Direct coupling of catharanthi ...... f (+)- and ent-(-)-vinblastine
@en
prefLabel
Direct coupling of catharanthi ...... f (+)- and ent-(-)-vinblastine
@en
P2093
P2860
P356
P1476
Direct coupling of catharanthi ...... f (+)- and ent-(-)-vinblastine
@en
P2093
Dale L Boger
David A Colby
Hayato Ishikawa
P2860
P304
P356
10.1021/JA078192M
P407
P577
2008-01-01T00:00:00Z