Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth.
about
Identifying druggable disease-modifying gene productsJak2 inhibitors: rationale and role as therapeutic agents in hematologic malignancies.Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screeningIntegrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617.The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo.A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growthHexim1, a Novel Regulator of Leptin Function, Modulates Obesity and Glucose DisposalProspect of JAK2 inhibitor therapy in myeloproliferative neoplasms.Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinasesRecent developments on JAK2 inhibitors: a patent review.A structure-function perspective of Jak2 mutations and implications for alternate drug design strategies: the road not taken.Everolimus-induced human keratinocytes toxicity is mediated by STAT3 inhibitionJak2 Tyrosine Kinase: A Potential Therapeutic Target for AT1 Receptor Mediated Cardiovascular Disease.
P2860
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P2860
Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Z3, a novel Jak2 tyrosine kina ...... diated pathologic cell growth.
@en
type
label
Z3, a novel Jak2 tyrosine kina ...... diated pathologic cell growth.
@en
prefLabel
Z3, a novel Jak2 tyrosine kina ...... diated pathologic cell growth.
@en
P2093
P2860
P1476
Z3, a novel Jak2 tyrosine kina ...... diated pathologic cell growth.
@en
P2093
Andrew Magis
David A Ostrov
Jacqueline Sayyah
Peter P Sayeski
Raul C Braylan
Robert W Allan
P2860
P304
P356
10.1158/1535-7163.MCT-08-0279
P577
2008-08-01T00:00:00Z