Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening - Wikidata - awgldk - TriplyDB

Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening

Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening

http://www.wikidata.org/entity/Q33616659

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Comprehensive structural and functional characterization of the human kinome by protein structure modeling and ligand virtual screening.Structural determinants of PERK inhibitor potency and selectivity Using free energy of binding calculations to improve the accuracy of virtual screening predictions.The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo.Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: significance of the para-hydroxyl orientation Structure-function correlation of G6, a novel small molecule inhibitor of Jak2: indispensability of the stilbenoid core.The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617.The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis.The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo.Cell death induced by the Jak2 inhibitor, G6, correlates with cleavage of vimentin filaments.The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth The recent medicinal chemistry development of Jak2 tyrosine kinase small molecule inhibitors.The use of structural biology in Janus kinase targeted drug discovery.Identification of myeloproliferative neoplasm drug agents via predictive simulation modeling: assessing responsiveness with micro-environment derived cytokines.Recent developments on JAK2 inhibitors: a patent review.How Does the L884P Mutation Confer Resistance to Type-II Inhibitors of JAK2 Kinase: A Comprehensive Molecular Modeling Study.The JAK2 pathway is activated in idiopathic pulmonary fibrosis.Identification of 8-Hydroxyquinoline Derivatives Active Against Somatic V658F Mutant JAK1-Dependent Cells.Jak2 Tyrosine Kinase: A Potential Therapeutic Target for AT1 Receptor Mediated Cardiovascular Disease.

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P2860

Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening

http://www.wikidata.org/entity/Q33616659

description

2009 nî lūn-bûn

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2009 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2009 թվականի մայիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Identification of a novel inhi ...... ucture-based virtual screening

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Identification of a novel inhi ...... ucture-based virtual screening

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type

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Identification of a novel inhi ...... ucture-based virtual screening

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Identification of a novel inhi ...... ucture-based virtual screening

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Identification of a novel inhi ...... ucture-based virtual screening

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J.BMCL.2009.04.138

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Bioorganic & Medicinal Chemistry Letters

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Identification of a novel inhi ...... ucture-based virtual screening

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P2093

Annet Kirabo

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Jacqueline Sayyah

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Kenneth S Zuckerman

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Kirpal S Bisht

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Lubomir Sokol

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Meghanath Gali

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Nicholas C Figueroa

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Peter P Sayeski

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Róbert Kiss

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P2860

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

Fragment-based discovery of JAK-2 inhibitors

ZINC--a free database of commercially available compounds for virtual screening

Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera.

Comparative protein modelling by satisfaction of spatial restraints

The Jak-Stat pathway in normal and perturbed hematopoiesis

The conserved box 1 motif of cytokine receptors is required for association with JAK kinases

Jak2 is essential for signaling through a variety of cytokine receptors

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

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