The inhibitor of apoptosis proteins as therapeutic targets in cancer.
about
Structures of BIR domains from human NAIP and cIAP2Antagonists induce a conformational change in cIAP1 that promotes autoubiquitinationDiscovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)The mechanism of peptide-binding specificity of IAP BIR domains.Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma.Antitumor and antiangiogenic effect of the dual EGFR and HER-2 tyrosine kinase inhibitor lapatinib in a lung cancer modelPoly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells.Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms.Immunity to the melanoma inhibitor of apoptosis protein (ML-IAP; livin) in patients with malignant melanoma.Rosette nanotubes inhibit bovine neutrophil chemotaxis.Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunitiesHost insect inhibitor-of-apoptosis SfIAP functionally replaces baculovirus IAP but is differentially regulated by Its N-terminal leader.Cytotoxic activity and apoptosis-inducing potential of di-spiropyrrolidino and di-spiropyrrolizidino oxindole andrographolide derivatives.HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerizationTherapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatmentPotent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells.TRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor of apoptosis (XIAP).A novel antagonist to the inhibitors of apoptosis (IAPs) potentiates cell death in EGFR-overexpressing non-small-cell lung cancer cellsApoptosis in cancer: from pathogenesis to treatment.Genome-wide expression and copy number analysis identifies driver genes in gingivobuccal cancersSurvivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis.Direct estimation of differential networksSoluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers.Lipid-conjugated Smac analogues.A novel small-molecule IAP antagonist, AZD5582, draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer.A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like SynoviocytesExpression of the IAP protein family acts cooperatively to predict prognosis in human bladder cancer patients.Regulation of apoptosis by XIAP ubiquitin-ligase activityRecurrent overexpression of c-IAP2 in EBV-associated nasopharyngeal carcinomas: critical role in resistance to Toll-like receptor 3-mediated apoptosisPERK-dependent regulation of IAP translation during ER stress.Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?Cytoprotective effects of IAPs revealed by a small molecule antagonist.A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice.Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma.Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer.IAP-targeted therapies for cancer.X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists.Locoregional intravascular viral therapy of cancer: precision guidance for Paris's arrow?
P2860
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P2860
The inhibitor of apoptosis proteins as therapeutic targets in cancer.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The inhibitor of apoptosis proteins as therapeutic targets in cancer.
@en
type
label
The inhibitor of apoptosis proteins as therapeutic targets in cancer.
@en
prefLabel
The inhibitor of apoptosis proteins as therapeutic targets in cancer.
@en
P1476
The inhibitor of apoptosis proteins as therapeutic targets in cancer.
@en
P2093
Domagoj Vucic
Wayne J Fairbrother
P304
P356
10.1158/1078-0432.CCR-07-0729
P407
P577
2007-10-01T00:00:00Z