Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells - Wikidata - awgldk - TriplyDB

Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells

Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells

http://www.wikidata.org/entity/Q37000350

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The hedgehog pathway in triple-negative breast cancer Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2 RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Role of RUNX2 in Breast Carcinogenesis 15-deoxy-δ12,14-prostaglandin j2 inhibits osteolytic breast cancer bone metastasis and estrogen deficiency-induced bone loss Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions.RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland.Runx1 stabilizes the mammary epithelial cell phenotype and prevents epithelial to mesenchymal transition.Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy.Bone metastasis-related signaling pathways in breast cancers stratified by estrogen receptor status MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements.Differential effects of RUNX2 on the androgen receptor in prostate cancer: synergistic stimulation of a gene set exemplified by SNAI2 and subsequent invasiveness.The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues.Prostate cancer regulatory networks hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3.The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells.Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis.A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes Metastatic bone disease: role of transcription factors and future targets.Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer.The Role of RUNX2 in Osteosarcoma Oncogenesis.Breast cancer metastasis to the bone: mechanisms of bone loss TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling Runx2-Smad signaling impacts the progression of tumor-induced bone disease ODAM Expression Inhibits Human Breast Cancer Tumorigenesis.Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility Sonic hedgehog regulates osteoblast function by focal adhesion kinase signaling in the process of fracture healing.Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease.Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway.Metastatic breast cancer cells inhibit osteoblast differentiation through the Runx2/CBFβ-dependent expression of the Wnt antagonist, sclerostin.Myeloma cell-derived Runx2 promotes myeloma progression in bone.Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility.In vivo tibial compression decreases osteolysis and tumor formation in a human metastatic breast cancer model.Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1 Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2.Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells.Role of Runx2 phosphorylation in prostate cancer and association with metastatic disease.The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis.

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Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells

http://www.wikidata.org/entity/Q37000350

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on October 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Runx2 transcriptional activati ...... pathway in breast cancer cells

@en

Runx2 transcriptional activati ...... athway in breast cancer cells.

@nl

type

label

Runx2 transcriptional activati ...... pathway in breast cancer cells

@en

Runx2 transcriptional activati ...... athway in breast cancer cells.

@nl

prefLabel

Runx2 transcriptional activati ...... pathway in breast cancer cells

@en

Runx2 transcriptional activati ...... athway in breast cancer cells.

@nl

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0008-5472.CAN-08-1078

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Cancer Research

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Runx2 transcriptional activati ...... pathway in breast cancer cells

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Andre J van Wijnen

http://www.w3.org/2001/XMLSchema#string

Gary S Stein

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Jane B Lian

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Janet L Stein

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Jason Dobson

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Jitesh Pratap

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John J Wixted

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Karthiga Devi Gokul

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Sadiq Hussain

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Tripti Gaur

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P2860

The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention

Hedgehog signaling pathway and gastric cancer

Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation

A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells

The RUNX genes: gain or loss of function in cancer

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein

PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways

Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog

Metastasis to bone: causes, consequences and therapeutic opportunities

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7795-7802

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scholarly article

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10.1158/0008-5472.CAN-08-1078

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19

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68

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Sayyed K. Zaidi

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2008-10-01T00:00:00Z

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18829534

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2596479

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