Normal human fibroblasts are resistant to RAS-induced senescence
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P1343
Cytoplasmic poly(A) binding proteins regulate telomerase activity and cell growth in human papillomavirus type 16 E6-expressing keratinocytesTowards a Better Understanding of the Molecular Mechanisms Involved in Sunlight-Induced MelanomaSynthetic lethal screens as a means to understand and treat MYC-driven cancersc-Myc accelerates S-phase and requires WRN to avoid replication stressRas oncogenes: split personalitiesThe senescence-associated secretory phenotype: the dark side of tumor suppressionQuantitative model of cell cycle arrest and cellular senescence in primary human fibroblasts.Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamics.Spread of X-chromosome inactivation into autosomal sequences: role for DNA elements, chromatin features and chromosomal domainsRas activity regulates cyclin E degradation by the Fbw7 pathway.Transformation of human and murine fibroblasts without viral oncoproteins.A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli.The expression signature of in vitro senescence resembles mouse but not human aging.The minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assay.The role of hypoxia inducible factor-1 alpha in bypassing oncogene-induced senescenceAKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.Functional genomics identifies therapeutic targets for MYC-driven cancer.Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.Immortalized cells as experimental models to study cancer.Oxygen free radicals in cell senescence: are they signal transducers?BRAF(E600) in benign and malignant human tumours.Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells.Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.Controversial aspects of oncogene-induced senescence.Genetic and epigenetic changes in mammary epithelial cells identify a subpopulation of cells involved in early carcinogenesis.Gene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFβ.Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence.PI3K Acts in synergy with loss of PKC to elicit apoptosis via the UPR.C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells.Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells.Modulation of intracellular signaling pathways to induce apoptosis in prostate cancer cells.Uncoupling Oncogene-Induced Senescence (OIS) and DNA Damage Response (DDR) triggered by DNA hyper-replication: lessons from primary mouse embryo astrocytes (MEA).The Immortal Senescence.Chronic NF-kappaB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response.Human papillomavirus E6 proteins mediate resistance to interferon-induced growth arrest through inhibition of p53 acetylation.Real-time in vivo imaging of p16gene expression: a new approach to study senescence stress signaling in living animals.Ki-67 Contributes to Normal Cell Cycle Progression and Inactive X Heterochromatin in p21 Checkpoint-Proficient Human Cells.High-efficiency RNA-based reprogramming of human primary fibroblasts.Regulation of telomerase by human papillomaviruses.Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT.
P2860
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P2860
Normal human fibroblasts are resistant to RAS-induced senescence
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on April 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Normal human fibroblasts are resistant to RAS-induced senescence
@en
Normal human fibroblasts are resistant to RAS-induced senescence.
@nl
type
label
Normal human fibroblasts are resistant to RAS-induced senescence
@en
Normal human fibroblasts are resistant to RAS-induced senescence.
@nl
prefLabel
Normal human fibroblasts are resistant to RAS-induced senescence
@en
Normal human fibroblasts are resistant to RAS-induced senescence.
@nl
P2860
P1476
Normal human fibroblasts are resistant to RAS-induced senescence
@en
P2093
Denise A Galloway
Jennifer A Benanti
P2860
P304
P356
10.1128/MCB.24.7.2842-2852.2004
P407
P4510
P577
2004-04-01T00:00:00Z