Characterization of a single-chain T-cell receptor expressed in Escherichia coli
about
Selection of functional T cell receptor mutants from a yeast surface-display libraryNew design of MHC class II tetramers to accommodate fundamental principles of antigen presentationPeriplasmic expression of soluble single chain T cell receptors is rescued by the chaperone FkpA.Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors.Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.T Cell Receptor Engineering and Analysis Using the Yeast Display Platform.Binding of soluble natural ligands to a soluble human T-cell receptor fragment produced in Escherichia coli.A general method for facilitating heterodimeric pairing between two proteins: application to expression of alpha and beta T-cell receptor extracellular segments.Solution mapping of T cell receptor docking footprints on peptide-MHC.Functional three-domain single-chain T-cell receptorsA bacterially expressed single-chain Fv construct from the 2B4 T-cell receptor.A T cell receptor V alpha domain expressed in bacteria: does it dimerize in solution?Immunization with soluble BDC 2.5 T cell receptor-immunoglobulin chimeric protein:antibody specificity and protection of nonobese diabetic mice against adoptive transfer of diabetes by maternal immunization.Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewingMedical applications of single-chain antibodies.Covalent assembly of a soluble T cell receptor-peptide-major histocompatibility class I complex.In-cell PCR from mRNA: amplifying and linking the rearranged immunoglobulin heavy and light chain V-genes within single cells.Transgenic TCR expression: comparison of single chain with full-length receptor constructs for T-cell function.Antigen recognition and targeted delivery by the single-chain Fv.Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragmentsConformational integrity and ligand binding properties of a single chain T-cell receptor expressed in Escherichia coli.Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition.Directed evolution of a stable scaffold for T-cell receptor engineering.
P2860
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P2860
Characterization of a single-chain T-cell receptor expressed in Escherichia coli
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on May 1992
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Characterization of a single-chain T-cell receptor expressed in Escherichia coli
@en
Characterization of a single-chain T-cell receptor expressed in Escherichia coli.
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type
label
Characterization of a single-chain T-cell receptor expressed in Escherichia coli
@en
Characterization of a single-chain T-cell receptor expressed in Escherichia coli.
@nl
prefLabel
Characterization of a single-chain T-cell receptor expressed in Escherichia coli
@en
Characterization of a single-chain T-cell receptor expressed in Escherichia coli.
@nl
P2093
P2860
P356
P1476
Characterization of a single-chain T-cell receptor expressed in Escherichia coli
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.10.4759
P407
P577
1992-05-01T00:00:00Z