Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition.
about
The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cellsT Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular FlexibilityConformational Melding Permits a Conserved Binding Geometry in TCR Recognition of Foreign and Self Molecular MimicsTCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct MechanismsIncreased peptide contacts govern high affinity binding of a modified TCR whilst maintaining a native pMHC docking modeT-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex InteractionsComputational Design of the Affinity and Specificity of a Therapeutic T Cell ReceptorStructure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.Stabilizing mutations increase secretion of functional soluble TCR-Ig fusion proteins.The basis for limited specificity and MHC restriction in a T cell receptor interface.Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes.Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramersT cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cellsSoluble T-cell receptors produced in human cells for targeted delivery.Facilitating matched pairing and expression of TCR chains introduced into human T cells.A T-cell receptor associated with naturally occurring human tumor immunity.Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens.Repertoire of the alpha beta T-cell receptor in the intestine.Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface.CD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells.Methods for quantifying T cell receptor binding affinities and thermodynamics.Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers.Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors.Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers.Tricks with tetramers: how to get the most from multimeric peptide-MHC.MHC-peptide tetramers for the analysis of antigen-specific T cells.Structural and biophysical determinants of αβ T-cell antigen recognition.The molecular determinants of CD8 co-receptor function.Structural and dynamic control of T-cell receptor specificity, cross-reactivity, and binding mechanism.Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer.Phage Display Engineered T Cell Receptors as Tools for the Study of Tumor Peptide-MHC Interactions.Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers.Combinations of affinity-enhancing mutations in a T cell receptor reveal highly nonadditive effects within and between complementarity determining regions and chains.Can oligomeric T-cell receptor be used as a tool to detect viral peptide epitopes on infected cells?Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.Identification of the cognate peptide-MHC target of T cell receptors using molecular modeling and force field scoring.On the path to TCR-directed therapeutics.Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties
P2860
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P2860
Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Design of soluble recombinant ...... rgeting and T cell inhibition.
@en
Design of soluble recombinant ...... rgeting and T cell inhibition.
@nl
type
label
Design of soluble recombinant ...... rgeting and T cell inhibition.
@en
Design of soluble recombinant ...... rgeting and T cell inhibition.
@nl
prefLabel
Design of soluble recombinant ...... rgeting and T cell inhibition.
@en
Design of soluble recombinant ...... rgeting and T cell inhibition.
@nl
P2093
P2860
P50
P356
P1476
Design of soluble recombinant ...... rgeting and T cell inhibition.
@en
P2093
Annelise Vuidepot
Bent K Jakobsen
Bruno Laugel
Daniel C Douek
Emma Gostick
Jonathan M Boulter
Laura E Crotty
Nikolai Lissin
P2860
P304
P356
10.1074/JBC.M409427200
P407
P577
2004-11-04T00:00:00Z