Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
about
Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunityNeural stem/progenitor cells in Alzheimer's diseaseTargeting innate immunity for neurodegenerative disorders of the central nervous systemImaging of Leukocyte Trafficking in Alzheimer's DiseaseMyeloid Dendritic Cells are Potential Players in Human Neurodegenerative DiseasesThe role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?How do immune cells support and shape the brain in health, disease, and aging?Neuroinflammation in Alzheimer's diseaseInnate immunity in Alzheimer's disease: a complex affairNeuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunityChemical dampening of Ly6C(hi) monocytes in the periphery produces anti-depressant effects in mice.Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse ModelCCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunctionToll-like Receptor 7 Mitigates Lethal West Nile Encephalitis via Interleukin 23-Dependent Immune Cell Infiltration and HomingCheckpoints to the Brain: Directing Myeloid Cell Migration to the Central Nervous SystemInnate Immunity Fights Alzheimer's DiseaseNeuroinflammation in Alzheimer's diseaseMechanisms of mononuclear phagocyte recruitment in Alzheimer's diseaseInteractions between inflammation, sex steroids, and Alzheimer's disease risk factorsFerulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic miceNetwork Topology Analysis of Post-Mortem Brain Microarrays Identifies More Alzheimer's Related Genes and MicroRNAs and Points to Novel Routes for Fighting with the DiseaseTGF-beta1 blockade of microglial chemotaxis toward Abeta aggregates involves SMAD signaling and down-regulation of CCL5Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brainMicroglia demonstrate age-dependent interaction with amyloid-β fibrilsReduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease.Role of the macrophage inflammatory protein-1alpha/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by beta-amyloid peptideTGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease.Intact memory in TGF-β1 transgenic mice featuring chronic cerebrovascular deficit: recovery with pioglitazoneTriterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype.HIV-1 stimulates nuclear entry of amyloid beta via dynamin dependent EEA1 and TGF-β/Smad signaling.Inflammation, microglia, and Alzheimer's disease.Can peripheral leukocytes be used as Alzheimer's disease biomarkers?YXQN Reduces Alzheimer's Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice.Overcoming the hurdles in using mouse genetic models that block TGF-beta signaling.Intestinal microbial dysbiosis aggravates the progression of Alzheimer's disease in DrosophilaMutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathologyInterleukin-1β mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mouse model of Alzheimer's disease.
P2860
Q24642507-F3D6158B-A9D1-4B5D-B2A1-B87575F3F145Q26738352-D9597BE0-4460-4B6F-B696-FF4B74AB455EQ26744219-4078C25D-4067-4E5B-A7BC-603E30508D26Q26766489-8DF6132C-98EA-47F5-9430-80E184B028CAQ26770676-39489178-78B0-4D6C-AF75-2CBA47F41054Q26861263-CA979F9C-C54E-4CD4-A735-1260A8888F32Q26995364-22939042-81F8-4C18-9E8D-C78884E13348Q27004226-59F8F2FF-CE52-403A-8E0B-C8301D0A7163Q27006944-722A842A-464C-48AE-9395-4207B62D1715Q27027973-6943B228-16EB-47ED-92D8-86F6AC2A77B6Q27301483-12D901D2-5807-4DFC-B52A-79FC2361EF10Q27319559-9E9785C2-63FF-4D40-8FF8-426A7A2B4F04Q27346578-A5F30169-1114-4A97-9640-705D403C1920Q27488876-D2D91019-24FD-4F6A-AB0F-45B9DC078DF0Q28066906-E603D09D-5734-44B7-B36E-0A4E7D17FE1EQ28081826-1443962E-1477-458D-A1EA-9499370D715AQ28259238-FAF82FDB-C913-4C7E-AA70-4D7040036EC7Q28275105-2D3EFD1B-5FC5-4581-B0D6-CEBA8D2703B6Q28394967-5C38C077-E3F8-4170-9C6B-E805C7093420Q28486102-97456ADE-C075-4E4D-88F6-E7271A4D84C6Q28552595-B14F3FF4-EA63-4372-B846-0CF2FBC07318Q28568787-15B1F3D7-91C9-48E1-A609-335C530E297BQ28578526-E4B5E68F-696C-452A-A17E-D0DEA6FF32A4Q30427927-8A9C6EE9-24B6-45A1-8B20-40C9F92BEA5FQ30489145-CA762499-2BC6-42EA-8268-F1CB74877DF3Q30490518-89286EDB-A061-42A8-A50C-C3EE3956CE3EQ30498066-D7D26E18-F06E-46BA-9C87-4ED697B008EEQ30498345-631ACB4D-B597-45D6-93DC-0BA8B6584A26Q30499926-92355D15-BC57-446E-BFE0-BE92BE211B78Q30545790-541C12CC-7BE6-470E-A6BF-F78C682EE673Q33404963-2DC5A4FC-0E11-41A1-A5F0-120CC23412EFQ33570359-799E06EA-050B-4837-B29A-EAF9E79EA46EQ33604503-A9818486-1B8D-47D7-BAA3-7185E167D337Q33664099-97159F00-3FDA-4468-AF54-426FFBA2EB37Q33689076-A24AB5A8-8201-4FAE-B2C5-2F9F6E467E8DQ33715454-D887C591-F363-4D3A-9314-C5D4FE73407CQ33752778-A64600E4-0228-4795-ABD3-AF8B92661108Q33819038-4BC65792-E06F-4891-97DD-F4D40692C773Q33935822-F9CCA405-E578-4B1E-B5BA-7A2A07F7C0CFQ33996683-E3701126-67F9-4FA6-92B6-3205FE740065
P2860
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
@en
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
@nl
type
label
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
@en
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
@nl
prefLabel
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
@en
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
@nl
P2093
P2860
P356
P1433
P1476
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
@en
P2093
Christine A Szekely
Richard A Flavell
Ronald S Duman
Takashi Mori
Terrence Town
Yasmina Laouar
P2860
P2888
P304
P356
10.1038/NM1781
P407
P577
2008-06-01T00:00:00Z