Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. - Wikidata - awgldk - TriplyDB

Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding.

Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding.

http://www.wikidata.org/entity/Q37127180

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Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73 Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint Bub1 regulates chromosome segregation in a kinetochore-independent manner APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis KNL1: bringing order to the kinetochore Reconstituting the kinetochore–microtubule interface: what, why, and how Bub3-BubR1-dependent sequestration of Cdc20Fizzy at DNA breaks facilitates the correct segregation of broken chromosomes A Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration.Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2.Cdc20 is critical for meiosis I and fertility of female mice Defining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 Inhibition Structure of the mitotic checkpoint complex Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit Spatiotemporal regulation of the anaphase-promoting complex in mitosis TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment.Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis Reprogramming to pluripotency can conceal somatic cell chromosomal instability The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit Bub1 and Bub3 promote the conversion from monopolar to bipolar chromosome attachment independently of shugoshin Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation The spindle assembly checkpoint works like a rheostat rather than a toggle switch Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint.Molecular basis of APC/C regulation by the spindle assembly checkpoint.Arabidopsis COPPER MODIFIED RESISTANCE1/PATRONUS1 is essential for growth adaptation to stress and required for mitotic onset control.Molecular dynamics simulation on the conformational transition of the mad2 protein from the open to the closed state.Separating the spindle, checkpoint, and timer functions of BubR1 Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.The MPS1 family of protein kinases.Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.Recruitment of Mad1 to metaphase kinetochores is sufficient to reactivate the mitotic checkpoint.

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Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding.

http://www.wikidata.org/entity/Q37127180

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on January 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Unattached kinetochores cataly ...... prime Cdc20 for BubR1 binding.

@en

Unattached kinetochores cataly ...... prime Cdc20 for BubR1 binding.

@nl

type

label

Unattached kinetochores cataly ...... prime Cdc20 for BubR1 binding.

@en

Unattached kinetochores cataly ...... prime Cdc20 for BubR1 binding.

@nl

prefLabel

Unattached kinetochores cataly ...... prime Cdc20 for BubR1 binding.

@en

Unattached kinetochores cataly ...... prime Cdc20 for BubR1 binding.

@nl

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P356

J.DEVCEL.2008.11.005

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Developmental Cell

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Unattached kinetochores cataly ...... prime Cdc20 for BubR1 binding.

@en

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Anita Kulukian

http://www.w3.org/2001/XMLSchema#string

Don W Cleveland

http://www.w3.org/2001/XMLSchema#string

Joo Seok Han

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20

Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

Mitotic regulation of the human anaphase-promoting complex by phosphorylation

Determinants of conformational dimerization of Mad2 and its inhibition by p31comet

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.

Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores

Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

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105-117

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scholarly article

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10.1016/J.DEVCEL.2008.11.005

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1

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16

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2009-01-01T00:00:00Z

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23802579

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19154722

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2655205

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