Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum.
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Immune response and immunopathology during toxoplasmosisHost Organelle Hijackers: a similar modus operandi for Toxoplasma gondii and Chlamydia trachomatis: co-infection model as a tool to investigate pathogenesisUse and abuse of dendritic cells by Toxoplasma gondiiAntigenic peptide trimming by ER aminopeptidases--insights from structural studiesInterferon-gamma- and perforin-mediated immune responses for resistance against Toxoplasma gondii in the brainPersistence of Toxoplasma gondii in the central nervous system: a fine-tuned balance between the parasite, the brain and the immune systemEndoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune responseStructural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responsesAdmixture and recombination among Toxoplasma gondii lineages explain global genome diversityUnconventional Peptide Presentation by Major Histocompatibility Complex (MHC) Class I Allele HLA-A*02:01: BREAKING CONFINEMENT.Conserved protective mechanisms in radiation and genetically attenuated uis3(-) and uis4(-) Plasmodium sporozoitesDifferential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.The CD8 T-cell road to immunotherapy of toxoplasmosis.Impact of regulated secretion on antiparasitic CD8 T cell responses.The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum.Characterizing the specificity and cooperation of aminopeptidases in the cytosol and endoplasmic reticulum during MHC class I antigen presentationNF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS.Processing and presentation of antigens derived from intracellular protozoan parasites.Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans.Toxoplasma gondii: 25 years and 25 major advances for the fieldSubdominant/cryptic CD8 T cell epitopes contribute to resistance against experimental infection with a human protozoan parasite.Subcellular antigen location influences T-cell activation during acute infection with Toxoplasma gondiiModulation of innate immunity by Toxoplasma gondii virulence effectors.Protective Toxoplasma gondii-specific T-cell responses require T-cell-specific expression of protein kinase C-theta.Regulation of CD8+ T cell responses to infection with parasitic protozoa.Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT.Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6.The Toxoplasma gondii peptide AS15 elicits CD4 T cells that can control parasite burden.Secreted immunodominant Mycobacterium tuberculosis antigens are processed by the cytosolic pathway.Human immunome, bioinformatic analyses using HLA supermotifs and the parasite genome, binding assays, studies of human T cell responses, and immunization of HLA-A*1101 transgenic mice including novel adjuvants provide a foundation for HLA-A03 restriVirulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cellsLocation of the CD8 T cell epitope within the antigenic precursor determines immunogenicity and protection against the Toxoplasma gondii parasite.Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells.Proteases in MHC class I presentation and cross-presentationPolymorphic family of injected pseudokinases is paramount in Toxoplasma virulenceCD8 T Cells and Toxoplasma gondii: A New ParadigmMyD88-dependent protective immunity elicited by adenovirus 5 expressing the surface antigen 1 from Toxoplasma gondii is mediated by CD8(+) T lymphocytes.Evaluation of Toxoplasma gondii as a live vaccine vector in susceptible and resistant hosts.
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Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 29 June 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Immunodominant, protective res ...... in the endoplasmic reticulum.
@en
Immunodominant, protective res ...... in the endoplasmic reticulum.
@nl
type
label
Immunodominant, protective res ...... in the endoplasmic reticulum.
@en
Immunodominant, protective res ...... in the endoplasmic reticulum.
@nl
prefLabel
Immunodominant, protective res ...... in the endoplasmic reticulum.
@en
Immunodominant, protective res ...... in the endoplasmic reticulum.
@nl
P2093
P2860
P356
P1433
P1476
Immunodominant, protective res ...... g in the endoplasmic reticulum
@en
P2093
Anjali J Shastri
Ellen A Robey
Federico Gonzalez
Nathalie T Joncker
Nilabh Shastri
Tiffany Cheng
P2860
P304
P356
10.1038/NI.1629
P407
P577
2008-06-29T00:00:00Z