RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27
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The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligasesComparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 ComplexSAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradationRBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteinsInactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesisEndothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis.Targeting the overexpressed ROC1 induces G2 cell cycle arrest and apoptosis in esophageal cancer cellsGatekeeper of pluripotency: a common Oct4 transcriptional network operates in mouse eggs and embryonic stem cellsInactivation of SAG E3 ubiquitin ligase blocks embryonic stem cell differentiation and sensitizes leukemia cells to retinoid acid.Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesisSmall RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer TargetsmiR-194 targets RBX1 gene to modulate proliferation and migration of gastric cancer cells.Covalent NEDD8 conjugation increases RCAN1 protein stability and potentiates its inhibitory action on calcineurin.Knockdown of regulator of cullins-1 (ROC1) expression induces bladder cancer cell cycle arrest at the G2 phase and senescence.Inactivation of Sag/Rbx2/Roc2 e3 ubiquitin ligase triggers senescence and inhibits kras-induced immortalizationSAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradationErbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesisUbiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitorsSCF E3 ubiquitin ligases as anticancer targets.Characterization of SCF-Complex during Bovine Preimplantation DevelopmentA Shortest-Path-Based Method for the Analysis and Prediction of Fruit-Related Genes in Arabidopsis thalianaRegulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway.Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells.Transcriptional repression of p27 is essential for murine embryonic developmentRBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival.ROC1/RBX1 E3 ubiquitin ligase silencing suppresses tumor cell growth via sequential induction of G2-M arrest, apoptosis, and senescence.Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis.Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase.Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells.SAG/Rbx2-Dependent Neddylation Regulates T-Cell Responses.SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization.SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complex.Overexpression of RING box protein-1 (RBX1) associated with poor prognosis of non-muscle-invasive bladder transitional cell carcinoma.Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes.RING box protein-1 gene involved in flagellar disassembly of Dunaliella salina.Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II
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P2860
RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 26 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
RBX1/ROC1 disruption results i ...... ed by simultaneous loss of p27
@en
RBX1/ROC1 disruption results i ...... d by simultaneous loss of p27.
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type
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RBX1/ROC1 disruption results i ...... ed by simultaneous loss of p27
@en
RBX1/ROC1 disruption results i ...... d by simultaneous loss of p27.
@nl
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RBX1/ROC1 disruption results i ...... ed by simultaneous loss of p27
@en
RBX1/ROC1 disruption results i ...... d by simultaneous loss of p27.
@nl
P2093
P2860
P356
P1476
RBX1/ROC1 disruption results i ...... ed by simultaneous loss of p27
@en
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Mingjia Tan
Shannon W Davis
Thomas L Saunders
P2860
P304
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10.1073/PNAS.0812425106
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P577
2009-03-26T00:00:00Z