Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. - Wikidata - awgldk - TriplyDB

Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

http://www.wikidata.org/entity/Q37175962

about

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6 EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair The role of epigenetics in the pathology of diabetic complications Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging Epigenetics: a molecular link between environmental factors and type 2 diabetes Changes in Regenerative Capacity through Lifespan PRC2 during vertebrate organogenesis: a complex in transition Mechanisms of epigenetic regulation of leukemia onset and progression Translational implications of the β-cell epigenome in diabetes mellitus Emerging concepts of epigenetic dysregulation in hematological malignancies Epigenetic Regulation of Islet Development and Regeneration Defining the toxicology of aging Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex Jarid2 regulates mouse epidermal stem cell activation and differentiation miR-24 regulates menin in the endocrine pancreas Long noncoding RNA variations in cardiometabolic diseases.Islet biology, the CDKN2A/B locus and type 2 diabetes risk.Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration.Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy.Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration.EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy Roles of lncRNAs in pancreatic beta cell identity and diabetes susceptibility.Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate Impact papers on aging in 2009.Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras.Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice EZH2 couples pancreatic regeneration to neoplastic progression.The molecular balancing act of p16(INK4a) in cancer and aging.Glucose and aging control the quiescence period that follows pancreatic beta cell replication Age-related impairment of pancreatic Beta-cell function: pathophysiological and cellular mechanisms.Mutations in EZH2 cause Weaver syndrome.Pancreatic beta-cells: from generation to regeneration.Dynamic patterns of histone lysine methylation in the developing retina.Regulation of senescence in cancer and aging.Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice.Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes.

P2860

Q24293466-27C812A5-79E5-4FA3-9F76-E2FA0D0D8CCF Q24608279-7266CACC-DFD4-4721-BAC9-E70E402F0EB1 Q24609124-753D9604-2F0A-4E00-B9C4-1FD77EC7FC03 Q24646862-7D18569E-ECAC-44D8-A4E6-8954BA6B871C Q24652830-99FDBF21-56E8-4F5F-9AB4-C676CBE34720 Q26778013-D3BC199E-9A50-4422-968E-D0D7FF57127A Q26821792-0389CDF9-379C-49CE-B1F4-6B7F121B1A4A Q26861785-D1252ABC-34B0-4E72-8010-4C6614AB243F Q27009451-29DC712B-24DA-494E-842C-7654CE47429B Q28074522-1D0EEFCF-669B-44C1-8701-BE3F7581E00B Q28109395-361E3795-AEA0-4E3C-81EB-B52846A24A19 Q28389491-D49BEC9B-B27A-4515-B0A2-8C58D3481378 Q28506102-30E7364F-FFB8-485D-9982-CD02FEF4A873 Q28506827-3536C0BC-536F-4B08-900D-44E6795B6616 Q28507526-5D40A0A7-C9BC-4786-893B-8F2535639EC7 Q28593305-A774B8D9-8101-43EB-A42C-5B2D1313B15A Q28593937-9C4FDE21-EBD2-4F90-A9EC-82610C7495DE Q30249603-38791220-FADB-4816-B336-5227DD27FB0A Q30251397-2C9ED92A-6BCC-4F78-B1E4-A9A099357ADC Q30433884-2A80FE07-5F3E-4F24-9AA2-1AB6BF0D696C Q30442295-0250485A-1286-4143-8550-0A921FC8E330 Q30496377-1F0F5E1D-9F47-4BC8-95C4-F60EE46AADDA Q33577410-8375B15D-EB21-40B2-BFB6-49BF796804D4 Q33815652-85501909-6936-4581-8FB9-08724D91B6E1 Q33827444-61AAC5BC-3145-4C56-BFFC-7849D0779FD8 Q33838645-3394E0ED-CC72-47C5-A005-2FF1BC1514F5 Q33854215-AF310E14-EFA4-4905-9016-A00742318019 Q33933332-48F06533-9316-4664-927C-8B22EC20619C Q33993882-27021A51-8644-4341-B23A-A9ED6F7A4A79 Q34030984-A828FDE7-F654-47CC-BF71-37FB54D05355 Q34038585-0B2B97FA-AAA3-4E4E-AF1D-FA289E640063 Q34107602-B56D40EC-1C56-40CB-8EA6-9D8DCE90574F Q34127184-10F06C4A-82C2-4DA9-9B61-68FA2E36F033 Q34241216-7287D5C7-7B4D-4685-A637-72C84DA34E0E Q34258845-9FA929C1-D194-4200-A640-584E23C1D261 Q34662331-296F349F-4D58-4A31-8F92-5163F55F2A4D Q34665706-0E8DE9EB-FECA-40D6-8FB6-4AFFE3E16737 Q34718783-EE99E8FE-2CAC-4B54-9C2F-2F273494F19A Q34750222-EF8E79AF-23A9-45F0-973B-D00F58E03232 Q34754281-128C0C71-5402-4A64-90E8-8B5277298AED

P2860

Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

http://www.wikidata.org/entity/Q37175962

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on April 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Polycomb protein Ezh2 regulate ...... neration in diabetes mellitus.

@en

Polycomb protein Ezh2 regulate ...... neration in diabetes mellitus.

@nl

type

label

Polycomb protein Ezh2 regulate ...... neration in diabetes mellitus.

@en

Polycomb protein Ezh2 regulate ...... neration in diabetes mellitus.

@nl

prefLabel

Polycomb protein Ezh2 regulate ...... neration in diabetes mellitus.

@en

Polycomb protein Ezh2 regulate ...... neration in diabetes mellitus.

@nl

P1433

Q37175962-FD231DDE-702F-4DB4-9D94-B03D8A9A3512

P1476

Q37175962-844FCDD1-224F-4A8F-8072-54274B145D93

P2093

Q37175962-0FCD3F9D-41EF-40C3-86E0-F067797AC372

Q37175962-10CE8887-60DE-48D7-B764-7A126D169A79

Q37175962-48BAEC2A-A4F6-4330-B4AA-08CD2CF979E3

Q37175962-4D9B7117-AA23-4899-86FC-EDDCFBDBE175

Q37175962-6B963AF0-ACF4-4EB8-B3B5-470AB61D62DB

Q37175962-EBE15B38-C01B-4255-94EE-E62A79A09E5E

P2860

Q37175962-0F886ED0-597B-441C-8FD8-1970239678FE

Q37175962-1215B4D4-63F3-47E2-A73F-AB211AEBAE4A

Q37175962-15D38287-55F0-4F40-8EF2-FD58FB320000

Q37175962-24ABB715-3B0F-4989-9AC0-BD829B6CF6B0

Q37175962-258C6109-3B46-4D01-9217-7D1BF1E633E5

Q37175962-2687AF92-17F6-41C3-B094-53CA4710407C

Q37175962-30ECF1EE-84B4-48C1-AF85-6B00738D95D5

Q37175962-439B4911-A769-481E-86D4-8F144FE14385

Q37175962-4D9E0D51-DC7C-46F4-BA02-E1C024E6EADD

Q37175962-50588C0F-BE26-4A97-AA08-0C94DD209EF3

P304

Q37175962-02447174-ACA7-4BB9-9F3B-193D7849E135

P31

Q37175962-5AC6E5DB-881A-4025-8C02-DF7242196FAF

P356

Q37175962-70BCB2CA-3712-40C4-93BA-2BD2CF2087A9

P433

Q37175962-CC9E85E8-5709-4842-893F-579FFDEB1377

P478

Q37175962-60AE4CC4-0768-4689-A1AF-E3F4BE2DC8D6

P50

Q37175962-640D2EBD-2FFB-4A86-B3DC-820EAE78BE8C

P577

Q37175962-1DF97AB9-D304-4DF7-8FA6-365A8AD03DB3

P5875

Q37175962-B27A92A3-401E-4F63-AC42-E01F04146199

P698

Q37175962-1A267AA4-CBD9-488A-A99E-05EA0A38632A

P932

Q37175962-488FE986-562C-4D8D-ABEF-8D6E24686506

P356

P1433

Genes & Development

P1476

Polycomb protein Ezh2 regulate ...... eneration in diabetes mellitus

@en

P2093

Alexander Tarakhovsky

http://www.w3.org/2001/XMLSchema#string

Hainan Chen

http://www.w3.org/2001/XMLSchema#string

Juan L Contreras

http://www.w3.org/2001/XMLSchema#string

Rita Bottino

http://www.w3.org/2001/XMLSchema#string

Seung K Kim

http://www.w3.org/2001/XMLSchema#string

Xueying Gu

http://www.w3.org/2001/XMLSchema#string

P2860

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

p16INK4a induces an age-dependent decline in islet regenerative potential

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

Ink4a/Arf expression is a biomarker of aging

Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus

P304

975-985

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1101/GAD.1742509

http://www.w3.org/2001/XMLSchema#string

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

23

http://www.w3.org/2001/XMLSchema#string

P50

P577

2009-04-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

24355569

http://www.w3.org/2001/XMLSchema#string

P698

19390090

http://www.w3.org/2001/XMLSchema#string

P932

2675862

http://www.w3.org/2001/XMLSchema#string