C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence. - Wikidata - awgldk - TriplyDB

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.

http://www.wikidata.org/entity/Q37192706

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The many faces of hematopoietic stem cell heterogeneity Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish.EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors.Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia Disruption of the C/EBPα-miR-182 balance impairs granulocytic differentiation.C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis The Cebpa +37-kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells.The multifaceted functions of C/EBPα in normal and malignant haematopoiesis.The gene signature in CCAAT-enhancer-binding protein α dysfunctional acute myeloid leukemia predicts responsiveness to histone deacetylase inhibitors.The molecular basis of myeloid malignancies.DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish.The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets Factors.Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia.In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis.Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes.Acetylation of C/EBPα inhibits its granulopoietic function.C/EBPα is required for development of dendritic cell progenitors.Myeloid differentiation and the leukemia-initiating cell An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation.Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA.Developmental changes in hematopoietic stem cell properties.The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes.C/EBPα in normal and malignant myelopoiesis.Hematopoietic stem cells: concepts, definitions, and the new reality.Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.Detection of Imprinted Genes by Single-Cell Allele-Specific Gene Expression Runx Family Genes in Tissue Stem Cell Dynamics.C/EBPα deregulation as a paradigm for leukemogenesis.The presence of C/EBPα and its degradation are both required for TRIB2-mediated leukaemia.C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors CCAAT/Enhancer-binding Protein α (C/EBPα) Is Important for Osteoclast Differentiation and Activity.Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.Contrasting roles for C/EBPα and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects.Linking HSCs to their youth.C/EBPα is Regulated by the RANK Cytoplasmic IVVY535-538 Motif and Stimulates Osteoclastogenesis more Strongly than c-Fos.ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPα.CHD7 maintains neural stem cell quiescence and prevents premature stem cell depletion in the adult hippocampus.LSD1 inhibition exerts its anti-leukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML.

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C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.

http://www.wikidata.org/entity/Q37192706

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 17 March 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.

@en

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.

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type

label

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.

@en

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.

@nl

prefLabel

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.

@en

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.

@nl

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Nature Cell Biology

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C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.

@en

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Akira Kawasaki

http://www.w3.org/2001/XMLSchema#string

Daniel G Tenen

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Elena Levantini

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Giovanni Amabile

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Henry Yang

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Hong Zhang

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Junyan Zhang

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Meritxell Alberich-Jordà

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Min Ye

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Philipp B Staber

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P2860

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Molecular signatures of proliferation and quiescence in hematopoietic stem cells

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells

Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells

Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo

A novel normalization method for effective removal of systematic variation in microarray data.

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385-394

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scholarly article

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10.1038/NCB2698

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4

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15

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2013-03-17T00:00:00Z

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236055524

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23502316

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3781213

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