Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.
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Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control regionAn embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimerDistinct domains of erythroid Krüppel-like factor modulate chromatin remodeling and transactivation at the endogenous beta-globin gene promoterA tale of three fingers: the family of mammalian Sp/XKLF transcription factorsInduction of human fetal globin gene expression by a novel erythroid factor, NF-E4FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genesErythroid phenotypes associated with KLF1 mutationsMammalian Krüppel-like factors in health and diseasesKLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivoA global role for EKLF in definitive and primitive erythropoiesisKrüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variantsThe human beta-globin locus control regionThe role of the -50 region of the human gamma-globin gene in switchingProstate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway.Subcellular transport of EKLF and switch-on of murine adult beta maj globin gene transcription.Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificityAdult stage gamma-globin silencing is mediated by a promoter direct repeat element.Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor EklfGeneration of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencingRegulation of delta-aminolevulinic acid dehydratase by krüppel-like factor 1.KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome.Regulation of the globin genes.Transcriptional control of erythropoiesis: emerging mechanisms and principles.Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.Use of the zebrafish larvae as a model to study cigarette smoke condensate toxicityLineage-specific activators affect beta-globin locus chromatin in multipotent hematopoietic progenitors.Update on fetal hemoglobin gene regulation in hemoglobinopathiesContext-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.Enhancers regulate progression of development in mammalian cellsErythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivativesThe beta-globin promoter is important for recruitment of erythroid Krüppel-like factor to the locus control region in erythroid cellsAltered regulation of beta-like globin genes by a redesigned erythroid transcription factorRepression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoterCREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation.Linear distance from the locus control region determines epsilon-globin transcriptional activity.Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases.Advances in the understanding of haemoglobin switching.Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders.Krüppel-like zinc fingers bind to nuclear import proteins and are required for efficient nuclear localization of erythroid Krüppel-like factor.
P2860
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P2860
Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Silencing of human fetal globi ...... n gene activator protein EKLF.
@en
Silencing of human fetal globi ...... n gene activator protein EKLF.
@nl
type
label
Silencing of human fetal globi ...... n gene activator protein EKLF.
@en
Silencing of human fetal globi ...... n gene activator protein EKLF.
@nl
prefLabel
Silencing of human fetal globi ...... n gene activator protein EKLF.
@en
Silencing of human fetal globi ...... n gene activator protein EKLF.
@nl
P2093
P2860
P356
P1476
Silencing of human fetal globi ...... n gene activator protein EKLF.
@en
P2093
P2860
P304
12267-12271
P356
10.1073/PNAS.93.22.12267
P407
P577
1996-10-01T00:00:00Z