Identification and biochemical characterization of small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A
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Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular designSmall molecules showing significant protection of mice against botulinum neurotoxin serotype AFungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A.Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease.Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain ProteaseSynthesis and biological evaluation of botulinum neurotoxin a protease inhibitors.Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.Development and application of a cellular, gain-of-signal, bioluminescent reporter screen for inhibitors of type II secretion in Pseudomonas aeruginosa and Burkholderia pseudomallei.Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening.Charged and hydrophobic surfaces on the a chain of shiga-like toxin 1 recognize the C-terminal domain of ribosomal stalk proteinsSmall-molecule quinolinol inhibitor identified provides protection against BoNT/A in mice.Basic tetrapeptides as potent intracellular inhibitors of type A botulinum neurotoxin protease activity.Cleavage of SNAP25 and its shorter versions by the protease domain of serotype A botulinum neurotoxin.Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulismSeparation of Betti Reaction Product Enantiomers: Absolute Configuration and Inhibition of Botulinum Neurotoxin ANewly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays.Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxicationTargeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cellsThe C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft.Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain.Spore-forming Bacilli and Clostridia in human disease.Molecular structures and functional relationships in clostridial neurotoxins.Targeting bacterial toxins.Current strategies for designing antidotes against botulinum neurotoxins.Challenges in searching for therapeutics against Botulinum Neurotoxins.Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain.Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.Engineering of Botulinum Neurotoxins for Biomedical Applications.Discovery of a fluorene class of compounds as inhibitors of botulinum neurotoxin serotype E by virtual screening
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P2860
Identification and biochemical characterization of small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Identification and biochemical ...... otulinum neurotoxin serotype A
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Identification and biochemical ...... tulinum neurotoxin serotype A.
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type
label
Identification and biochemical ...... otulinum neurotoxin serotype A
@en
Identification and biochemical ...... tulinum neurotoxin serotype A.
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prefLabel
Identification and biochemical ...... otulinum neurotoxin serotype A
@en
Identification and biochemical ...... tulinum neurotoxin serotype A.
@nl
P2093
P2860
P356
P1476
Identification and biochemical ...... otulinum neurotoxin serotype A
@en
P2093
David C H Yang
Huiguo Lai
Istvan Enyedy
Leonard A Smith
Marco A Carrington
Nizamettin Gul
Vanessa S Eccard
Vicki A Montgomery
Virginia Roxas-Duncan
P2860
P304
P356
10.1128/AAC.00141-09
P407
P577
2009-06-15T00:00:00Z