Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.
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New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancerFinding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging MoleculesIntrinsic Order and Disorder in the Bcl-2 Member Harakiri: Insights into Its Proapoptotic ActivityHigh-quality NMR structure of human anti-apoptotic protein domain Mcl-1(171-327) for cancer drug designBh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysisMantle cell lymphoma in the era of precision medicine-diagnosis, biomarkers and therapeutic agentsEndoplasmic reticulum membrane reorganization is regulated by ionic homeostasisProteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cellsIntrinsic Resistance to 5-Fluorouracil in a Brain Metastatic Variant of Human Breast Cancer Cell Line, MDA-MB-231BRPhase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors.3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.Voltage-dependent anion channel 1-based peptides interact with Bcl-2 to prevent antiapoptotic activity.Emerging Bcl-2 inhibitors for the treatment of cancer.Inhibition of Bfl-1 with N-aryl maleimides.Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells.Characterization of a novel interaction between Bcl-2 members Diva and Harakiri.ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21((CIP1/WAF1)) in human cancer cells.Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factorsIFN-γ regulates survival and function of tumor-induced CD11b+ Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1.MicroRNA-195 promotes apoptosis in mouse podocytes via enhanced caspase activity driven by BCL2 insufficiency.BH3-only proteins in apoptosis and beyond: an overview.Function of UDP-glucuronosyltransferase 2B17 (UGT2B17) is involved in endometrial cancerABT-737 overcomes resistance to immunotoxin-mediated apoptosis and enhances the delivery of pseudomonas exotoxin-based proteins to the cell cytosol.Pharmacokinetic modeling of an induction regimen for in vivo combined testing of novel drugs against pediatric acute lymphoblastic leukemia xenografts.Merkel cell carcinoma dependence on bcl-2 family members for survival.Caspase functions in cell death and disease.PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status.Overcoming multiple drug resistance mechanisms in medulloblastoma.Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactionsMiR-133b regulates bladder cancer cell proliferation and apoptosis by targeting Bcl-w and Akt1.The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder.Colorectal cancer stem cells and their implications for novel anticancer therapy.The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent mannerAmphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanismsInduction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interactionNavitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL.Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8.Chemistry and biology of the caged Garcinia xanthones.
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Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 September 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.
@en
Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.
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type
label
Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.
@en
Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.
@nl
prefLabel
Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.
@en
Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.
@nl
P2093
P2860
P356
P1476
Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.
@en
P2093
P2860
P2888
P304
P356
10.1038/CDD.2008.137
P577
2008-09-19T00:00:00Z