Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma. - Wikidata - awgldk - TriplyDB

Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma.

Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma.

http://www.wikidata.org/entity/Q37318631

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Brain tumor modeling using the CRISPR/Cas9 system: state of the art and view to the future Pre-Clinical Models of Diffuse Intrinsic Pontine Glioma Epigenetic dysregulation: a novel pathway of oncogenesis in pediatric brain tumors PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma Diffuse Intrinsic Pontine Glioma: New Pathophysiological Insights and Emerging Therapeutic Targets Cellular characterization of ultrasound-stimulated microbubble radiation enhancement in a prostate cancer xenograft model.Oncogene interactions are required for glioma development and progression as revealed by a tissue specific transgenic mouse model A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG).Manganese-containing Prussian blue nanoparticles for imaging of pediatric brain tumors.Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas.Astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment.Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma.Chloroquine or chloroquine-PI3K/Akt pathway inhibitor combinations strongly promote γ-irradiation-induced cell death in primary stem-like glioma cells Vamorolone, a dissociative steroidal compound, reduces pro-inflammatory cytokine expression in glioma cells and increases activity and survival in a murine model of cortical tumor.Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma.The challenges and the promise of molecular targeted therapy in malignant gliomas.Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling.The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma.A standardized autopsy procurement allows for the comprehensive study of DIPG biology.Review: insights gained from modelling high-grade glioma in the mouse.The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.The current state of targeted agents in rectal cancer.BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma.Molecular profiling of childhood cancer: Biomarkers and novel therapies Development of a DIPG Orthotopic Model in Mice Using an Implantable Guide-Screw System.Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies.B7-H3, a potential therapeutic target, is expressed in diffuse intrinsic pontine glioma.Tumor location, but not H3.3K27M, significantly influences the blood-brain-barrier permeability in a genetic mouse model of pediatric high-grade glioma A Novel Mouse Model of Diffuse Intrinsic Pontine Glioma Initiated in Pax3-Expressing Cells.Pediatric gliomas as neurodevelopmental disorders ABCG2 and ABCB1 Limit the Efficacy of Dasatinib in a PDGF-B-Driven Brainstem Glioma Model.Differences between brainstem gliomas in juvenile and adult rats.Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas.An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testing Dual Inhibition of PI3K/AKT and MEK/ERK Pathways Induces Synergistic Antitumor Effects in Diffuse Intrinsic Pontine Glioma Cells.Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge.Genetic modeling of gliomas in mice: new tools to tackle old problems.

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Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma.

http://www.wikidata.org/entity/Q37318631

description

article científic

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article scientifique

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artigo científico

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bilimsel makale

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scientific article published on 02 March 2010

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vedecký článok

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vetenskaplig artikel

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vědecký článek

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name

Preclinical evaluation of radi ...... ate model of brainstem glioma.

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Preclinical evaluation of radi ...... ate model of brainstem glioma.

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Preclinical evaluation of radi ...... ate model of brainstem glioma.

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Preclinical evaluation of radi ...... ate model of brainstem glioma.

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Preclinical evaluation of radi ...... ate model of brainstem glioma.

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Preclinical evaluation of radi ...... ate model of brainstem glioma.

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0008-5472.CAN-09-2503

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Cancer Research

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Preclinical evaluation of radi ...... ate model of brainstem glioma.

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Dolores Hambardzumyan

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Eric C Holland

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Jason T Huse

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Karim Helmy

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Oren J Becher

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Rebecca L Hiner

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Sarah Gall

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Steffen Albrecht

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Talia R Walker

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Tobey J MacDonald

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P2860

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

Diffuse brainstem glioma in children: critical review of clinical trials.

Pediatric brain stem gliomas: a review.

Target-driven exploratory study of imatinib mesylate in children with solid malignancies by the Innovative Therapies for Children with Cancer (ITCC) European Consortium.

A human brainstem glioma xenograft model enabled for bioluminescence imaging.

Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas.

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma.

Molecular pathogenesis of pediatric astrocytic tumors.

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo.

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2548-2557

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10.1158/0008-5472.CAN-09-2503

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2010-03-02T00:00:00Z

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20197468

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3831613

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