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Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmissionSNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitroCurrent view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2Nitric oxide signaling modulates synaptic inhibition in the superior paraolivary nucleus (SPN) via cGMP-dependent suppression of KCC2.Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia.ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity.Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4.Zinc bells rang in Jerusalem!A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium.Redox regulation of intracellular zinc: molecular signaling in the life and death of neuronsThe neurophysiology and pathology of brain zinc.Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptorHomeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures.Endogenous zinc depresses GABAergic transmission via T-type Ca(2+) channels and broadens the time window for integration of glutamatergic inputs in dentate granule cells.Zinc: new clues to diverse roles in brain ischemia.New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.K-Cl cotransporter KCC2--a moonlighting protein in excitatory and inhibitory synapse development and function.Biological metals and metal-targeting compounds in major neurodegenerative diseases.The K(+)-Cl(-) Cotransporter KCC2 and Chloride Homeostasis: Potential Therapeutic Target in Acute Central Nervous System Injury.The Zn2+-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl- absorption, via basolateral KCC1, and reduces fluid loss.Insight into glutamate excitotoxicity from synaptic zinc homeostasisKnockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration.Kv3 channel assembly, trafficking and activity are regulated by zinc through different binding sites.Anomalous levels of Cl- transporters cause a decrease of GABAergic inhibition in human peritumoral epileptic cortex.
P2860
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P2860
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 10 May 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Intracellular zinc inhibits KCC2 transporter activity
@en
Intracellular zinc inhibits KCC2 transporter activity.
@nl
type
label
Intracellular zinc inhibits KCC2 transporter activity
@en
Intracellular zinc inhibits KCC2 transporter activity.
@nl
prefLabel
Intracellular zinc inhibits KCC2 transporter activity
@en
Intracellular zinc inhibits KCC2 transporter activity.
@nl
P2093
P2860
P356
P1433
P1476
Intracellular zinc inhibits KCC2 transporter activity
@en
P2093
Chen Abramovitch-Dahan
Elias Aizenman
Israel Sekler
Mandar A Aras
Megan E Knoch
Michal Dagan-Rabin
Michal Hershfinkel
P2860
P2888
P304
P356
10.1038/NN.2316
P407
P50
P577
2009-05-10T00:00:00Z
P5875
P6179
1021368181