The carboxyl-terminal valine residues of proTGF alpha are required for its efficient maturation and intracellular routing.
about
Unique carboxyl-terminal sequences of wild type and alternatively spliced variant forms of transforming growth factor-alpha precursors mediate specific interactions with ErbB4 and ErbB2Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells.Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cellsTransmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55Testing reported associations of genetic risk factors for oral clefts in a large Irish study populationThe transmembrane domain of TACE regulates protein ectodomain sheddingTransmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognitionThe PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysisMetalloprotease disintegrin-mediated ectodomain shedding of EGFR ligands promotes intestinal epithelial restitutionA biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activationAge-related neuronal loss in the cochlea is not delayed by synaptic modulation.Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency.The membrane-anchoring domain of epidermal growth factor receptor ligands dictates their ability to operate in juxtacrine modeRhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog SpitzFrom wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease.Structural requirements for the tissue-specific and tissue-general functions of the Caenorhabditis elegans epidermal growth factor LIN-3.Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis.Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx.Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cellsRhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFαRoles of transforming growth factor-alpha in mammary development and disease.Mutagenesis reveals a role for epidermal growth factor receptor extracellular subdomain IV in ligand binding.Distinct stages in the recognition, sorting, and packaging of proTGFα into COPII-coated transport vesicles.The C-terminus of prenylin is important in forming a dimer conformation necessary for endoplasmic-reticulum-to-Golgi transport.Signals mediating cleavage of intercellular adhesion molecule-1.Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzyme.The carboxyl-terminal valine is required for transport of glycoprotein CD8 alpha from the endoplasmic reticulum to the intermediate compartment.The proamphiregulin cytoplasmic domain is required for basolateral sorting, but is not essential for constitutive or stimulus-induced processing in polarized Madin-Darby canine kidney cells.Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme.Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme.Stimulation of cleavage of membrane proteins by calmodulin inhibitors.N-terminal cleavage of proTGFalpha occurs at the cell surface by a TACE-independent activity.The extracellular linker of pro-neuregulin-alpha2c is required for efficient sorting and juxtacrine function.A specific endoplasmic reticulum export signal drives transport of stem cell factor (Kitl) to the cell surface.Human keratinocytes and tumor-derived cell lines express alternatively spliced forms of transforming growth factor-alpha mRNA, encoding precursors lacking carboxyl-terminal valine residues.Recycling of cell surface pro-transforming growth factor-{alpha} regulates epidermal growth factor receptor activation.Release of the neuregulin functional polypeptide requires its cytoplasmic tail.
P2860
Q22254700-0132B074-5B1A-475A-B034-F218DB4EA93CQ24307953-F2187BED-A4C3-4852-9E01-BF6F2A80AC79Q24324074-53DDAEF8-AC55-4013-ABB7-3A940360D98FQ24595955-DB671D11-CAC1-4365-95C2-7D859F144AF5Q24608802-2E616874-43D1-45B0-9033-4F5B482DBCACQ28258815-5F7BF0A9-37F4-4ABC-85D5-05FD9C8DBADBQ28278050-8E76861C-B891-4E06-9811-1A5186786C7CQ28510158-178E3EEC-0B63-43D5-86EC-0C8C82BF80A7Q28565754-2E781AC9-2EEB-46F8-97DA-0FBE7352777EQ28831250-CDD9D521-90D0-4D4B-88A9-CDCE671E4DAEQ30460360-B63F3E0B-6153-41F3-8494-83161AECC96EQ33201079-D8AA58BF-D31B-42AB-AD7D-642B3255DF95Q33841469-A3221981-6D5E-47D6-8FE0-D7256895D155Q33888173-D973A281-E415-4023-BD5D-2A5126182665Q33926726-40C3F84F-FD82-4B1C-A86D-B7E21E1A2B0CQ34608024-FC146B46-A9B0-4AE2-AFD3-B66F9CE2FD2CQ34886367-FCBA7D09-228A-439E-8401-A610E738A0C2Q35102168-6AC9A332-DD8B-4034-BD93-EC023E6B4AE2Q35545249-06CE244F-BD2F-4A7C-8981-3474C5AA9C78Q36255848-1B14E9F3-F77E-4A9D-A9FB-53946B718D05Q36970233-01125B5E-80DA-476B-8DBB-0CBC07A9F917Q37037476-A36527A9-A2E7-4C95-9D17-5DD7F74C11F6Q38320275-505BBD0D-D428-4FCC-8D93-780732B67397Q38774856-FA8E1A86-FD7D-4F3D-B169-1A9C7DCE7E97Q40586811-A6EDC929-E719-4169-AFF8-5E953CA13BDEQ40588017-245C3994-C970-456F-8754-2731F3F59383Q40774834-FA271168-2AAD-4183-AA25-5BBD18FAA87EQ40802100-E538D265-CE02-4DE9-AE7A-BF49B6B9E029Q40802434-92F1F1DD-4524-4BA3-B3E3-A743E1263CDAQ40881816-18575941-2E75-46B9-A1CA-004B2494AD12Q40881822-5A192B14-3A39-46C1-B49E-4933078A7C85Q40891936-C9262267-4747-43F2-A09E-B59964C4105FQ41956426-642B1003-BB3B-4E93-AA19-92F63481634AQ42131728-1A3DFC9E-D3CD-4C3E-B567-9A8C24C57463Q44289997-BA82C047-B3F4-4AE1-AC2C-4A4D1332F1F2Q47919787-E15E2573-A21A-43FC-B974-1D34584814B0Q51814356-B1FECD94-252F-4CDF-A28D-8991F54B2434Q54112869-8D74AC77-48B3-4F50-93F7-E5538C73A8E0
P2860
The carboxyl-terminal valine residues of proTGF alpha are required for its efficient maturation and intracellular routing.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1997
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The carboxyl-terminal valine r ...... ion and intracellular routing.
@en
The carboxyl-terminal valine r ...... ion and intracellular routing.
@nl
type
label
The carboxyl-terminal valine r ...... ion and intracellular routing.
@en
The carboxyl-terminal valine r ...... ion and intracellular routing.
@nl
prefLabel
The carboxyl-terminal valine r ...... ion and intracellular routing.
@en
The carboxyl-terminal valine r ...... ion and intracellular routing.
@nl
P2093
P2860
P356
P1476
The carboxyl-terminal valine r ...... ion and intracellular routing.
@en
P2093
P2860
P304
P356
10.1091/MBC.8.8.1619
P577
1997-08-01T00:00:00Z