Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.
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Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activationSimulation-based model selection for dynamical systems in systems and population biology.The role of suppressors of cytokine signalling in human neoplasmsAutophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activityShared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptideThe SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptorA new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptorThe prolactin receptor and severely truncated erythropoietin receptors support differentiation of erythroid progenitorsProteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis proteinActive conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains.Erythropoietin and erythropoietin receptor.Erythroid cells rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of phosphatidylinositol 3-kinase and Akt kinase: involvement of insulin receptor substrate-related adapter proteins.Advances in understanding the pathogenesis of primary familial and congenital polycythaemiaActivation of JAK2-V617F by components of heterodimeric cytokine receptorsControl of myeloid differentiation and survival by Stats.YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation.Acetylation modulates prolactin receptor dimerization.Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by databased modeling.Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities.Erythroblast transformation by the friend spleen focus-forming virus is associated with a block in erythropoietin-induced STAT1 phosphorylation and DNA binding and correlates with high expression of the hematopoietic phosphatase SHP-1.Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis.cAMP/PKA-mediated regulation of erythropoiesis.Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways.Mechanistic diversity of cytokine receptor signaling across cell membranes.Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation.Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.The SH2B1 adaptor protein associates with a proximal region of the erythropoietin receptor.Tyrosine 201 is required for constitutive activation of JAK2V617F and efficient induction of myeloproliferative disease in miceMechanisms of JAK/STAT pathway negative regulation by the short coreceptor Eye Transformer/Latran.Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cellsOligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail.Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway.Erythropoietin Does Not Enhance Skeletal Muscle Protein Synthesis Following Exercise in Young and Older Adults.Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation.EPO-receptor is present in mouse C2C12 and human primary skeletal muscle cells but EPO does not influence myogenesisThe erythropoietin receptor: molecular structure and hematopoietic signaling pathways.The role and regulation of erythropoietin (EPO) and its receptor in skeletal muscle: how much do we really know?Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor
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Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Multiple tyrosine residues in ...... r promote activation of STAT5.
@en
Multiple tyrosine residues in ...... r promote activation of STAT5.
@nl
type
label
Multiple tyrosine residues in ...... r promote activation of STAT5.
@en
Multiple tyrosine residues in ...... r promote activation of STAT5.
@nl
prefLabel
Multiple tyrosine residues in ...... r promote activation of STAT5.
@en
Multiple tyrosine residues in ...... r promote activation of STAT5.
@nl
P2860
P356
P1476
Multiple tyrosine residues in ...... r promote activation of STAT5.
@en
P2093
S Bergelson
P2860
P304
P356
10.1073/PNAS.93.16.8324
P407
P577
1996-08-01T00:00:00Z