Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.
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Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV.Bacillus anthracis GrlAV96A topoisomerase IV, a quinolone resistance mutation that does not affect the water-metal ion bridgeBypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design.Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae.Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteriaActivity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions.Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase.Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones.A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.Mechanism of quinolone action and resistance.Safety issues and drug-drug interactions with commonly used quinolones.Topoisomerases: Resistance versus Sensitivity, How Far We Can Go?Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase.Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance.Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities.Novel Bacterial Topoisomerase Inhibitors Exploit Asp83 and the Intrinsic Flexibility of the DNA Gyrase Binding Site.Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase.
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Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Overcoming target-mediated qui ...... dent drug-enzyme interactions.
@en
Overcoming target-mediated qui ...... dent drug-enzyme interactions.
@nl
type
label
Overcoming target-mediated qui ...... dent drug-enzyme interactions.
@en
Overcoming target-mediated qui ...... dent drug-enzyme interactions.
@nl
prefLabel
Overcoming target-mediated qui ...... dent drug-enzyme interactions.
@en
Overcoming target-mediated qui ...... dent drug-enzyme interactions.
@nl
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P2860
P356
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Overcoming target-mediated qui ...... ndent drug-enzyme interactions
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Charles L Turnbough
Gangqin Li
Katie J Aldred
Neil Osheroff
Robert J Kerns
Sylvia A McPherson
P2860
P304
P356
10.1021/CB400592N
P577
2013-09-30T00:00:00Z