Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells.
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Homo- and heterodimerization of APP family members promotes intercellular adhesion.Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organizationAmyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's diseaseCortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family membersPit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoterAPP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active ZoneGenetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor proteinTruncating mutations in APP cause a distinct neurological phenotype.APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories.Modeling chromosomes in mouse to explore the function of genes, genomic disorders, and chromosomal organizationA 2cM genome-wide scan of European Holstein cattle affected by classical BSE.Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression.Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortexFunction, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Cell surface heparan sulfate promotes replication of Toxoplasma gondii.Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase.Controlled somatic and germline copy number variation in the mouse modelA segmental deletion series generated by sister-chromatid transposition of Ac transposable elements in maizeThe intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signalingDeletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxiaDeletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus.Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway.Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse lineTranscription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer diseaseRegion-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus.Rapid generation of nested chromosomal deletions on mouse chromosome 2.Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system.APP Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones.Biology and pathophysiology of the amyloid precursor protein.APP physiological and pathophysiological functions: insights from animal models.Functions of the APP gene family in the nervous system: insights from mouse models.The gene or not the gene--that is the question: understanding the genetically engineered mouse phenotype.Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging.Role of APP for dendritic spine formation and stability.Functions of Aβ, sAPPα and sAPPβ : similarities and differences.Physiological functions of APP family proteins.Impaired theta-gamma coupling in APP-deficient mice.Not just amyloid: physiological functions of the amyloid precursor protein family.
P2860
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P2860
Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Generation of mice with a 200- ...... ation in embryonic stem cells.
@en
Generation of mice with a 200- ...... ation in embryonic stem cells.
@nl
type
label
Generation of mice with a 200- ...... ation in embryonic stem cells.
@en
Generation of mice with a 200- ...... ation in embryonic stem cells.
@nl
prefLabel
Generation of mice with a 200- ...... ation in embryonic stem cells.
@en
Generation of mice with a 200- ...... ation in embryonic stem cells.
@nl
P2093
P2860
P356
P1476
Generation of mice with a 200- ...... ation in embryonic stem cells.
@en
P2093
Gschwind M
Weissmann C
P2860
P304
P356
10.1073/PNAS.93.12.6158
P407
P577
1996-06-01T00:00:00Z