Substrate sequence effects on "hammerhead" RNA catalytic efficiency.
about
Structural organization of a viral IRES depends on the integrity of the GNRA motif.Efficient trans-cleavage of a stem-loop RNA substrate by a ribozyme derived from neurospora VS RNAEfficient ligation of the Schistosoma hammerhead ribozymeMolecular beacons as probes of RNA unfolding under native conditions.Catalytically active geometry in the reversible circularization of 'mini-monomer' RNAs derived from the complementary strand of tobacco ringspot virus satellite RNAThe Escherichia coli DEAD protein DbpA recognizes a small RNA hairpin in 23S rRNA.Construction of a directed hammerhead ribozyme library: towards the identification of optimal target sites for antisense-mediated gene inhibition.Identification of molecular interactions between P-site tRNA and the ribosome essential for translocationOligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicingGene augmentation for adRP mutations in RHO.The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization.A hammerhead ribozyme substrate and reporter for in vitro kinetoplastid RNA editingKinetic analysis of ribozyme-substrate complex formation in yeast.Prioritized selection of oligodeoxyribonucleotide probes for efficient hybridization to RNA transcriptsDifferences in the phosphate oxygen requirements for self-cleavage by the extended and prototypical hammerhead formsThe effect of structure in a long target RNA on ribozyme cleavage efficiency.Rational design of point mutation-selective antisense DNA targeted to codon 12 of Ha-ras mRNA in human cells.Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages.Design and specificity of hammerhead ribozymes against calretinin mRNA.Ribozyme therapy: RNA enzymes to the rescue.Kinetic characterization of intramolecular and intermolecular hammerhead RNAs with stem II deletions.Conformational heterogeneity and the determinants of tertiary stabilization in the hammerhead ribozyme from Dolichopoda cave crickets.A chemical interference study on the interaction of ribosomal protein L11 from Escherichia coli with RNA molecules containing its binding site from 23S rRNASpecificity of hammerhead ribozyme cleavageAlternative modes of self-cleavage by newt satellite 2 transcripts.Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo.Enhancement of ribozyme catalytic activity by a contiguous oligodeoxynucleotide (facilitator) and by 2'-O-methylation.Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistanceHammerhead ribozymes: importance of stem-loop II for activity.Crystallization of ribozymes and small RNA motifs by a sparse matrix approach.Use of intrinsic binding energy for catalysis by an RNA enzymeA DEAD-box RNA helicase promotes thermodynamic equilibration of kinetically trapped RNA structures in vivoSelection of efficient cleavage sites in target RNAs by using a ribozyme expression library.Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2' modificationsRibozyme-mediated reduction of wild-type and mutant cartilage oligomeric matrix protein (COMP) mRNA and proteinReconstitution of a group I intron self-splicing reaction with an activator RNA.Catalytic diversity of extended hammerhead ribozymesImplications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better.Importance of specific purine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme.The roles of the conserved pyrimidine bases in hammerhead ribozyme catalysis: evidence for a magnesium ion-binding site.
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Substrate sequence effects on "hammerhead" RNA catalytic efficiency.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1990
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Substrate sequence effects on "hammerhead" RNA catalytic efficiency.
@en
Substrate sequence effects on "hammerhead" RNA catalytic efficiency.
@nl
type
label
Substrate sequence effects on "hammerhead" RNA catalytic efficiency.
@en
Substrate sequence effects on "hammerhead" RNA catalytic efficiency.
@nl
prefLabel
Substrate sequence effects on "hammerhead" RNA catalytic efficiency.
@en
Substrate sequence effects on "hammerhead" RNA catalytic efficiency.
@nl
P2860
P356
P1476
Substrate sequence effects on "hammerhead" RNA catalytic efficiency.
@en
P2093
O C Uhlenbeck
P2860
P304
P356
10.1073/PNAS.87.5.1668
P407
P577
1990-03-01T00:00:00Z