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Eculizumab for treating patients with paroxysmal nocturnal hemoglobinuriaEculizumab for treating patients with paroxysmal nocturnal hemoglobinuriaThe C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10Allosteric Modulation of Chemoattractant ReceptorsComplement and macrophage crosstalk during process of angiogenesis in tumor progressionMolecular mechanisms of inflammation and tissue injury after major trauma--is complement the "bad guy"?Structural and functional characterization of human and murine C5a anaphylatoxinsStructural basis for therapeutic inhibition of complement C5Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targetsSTEC-HUS, atypical HUS and TTP are all diseases of complement activation.Cardiovascular complications in atypical haemolytic uraemic syndrome.Two cases of atypical hemolytic uremic syndrome (aHUS) and eosinophilic granulomatosis with polyangiitis (EGPA): a possible relationship.New milestones ahead in complement-targeted therapy.Inhibitors of C5 complement enhance vaccinia virus oncolysis.The interaction between C5a and sphingosine-1-phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation.Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain reliefCAWS administration increases the expression of interferon γ and complement factors that lead to severe vasculitis in DBA/2 miceComplement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration.Insights into the mechanism of C5aR inhibition by PMX53 via implicit solvent molecular dynamics simulations and dockingAssociation of C5aR1genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, ChinaComplement involvement in kidney diseases: From physiopathology to therapeutical targetingExperimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway.Differential Interaction of the Staphylococcal Toxins Panton-Valentine Leukocidin and γ-Hemolysin CB with Human C5a ReceptorsA simple PCR-based method for the rapid genotyping of inherited fifth complement component (C5)-deficient mice.Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling.CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis.Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study.Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiation.Applying complement therapeutics to rare diseases.Complement Activation in Placental Malaria.Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist.Progress and Trends in Complement TherapeuticsPresent and Future Therapies in Neuromyelitis Optica Spectrum DisordersNew approaches to the study of sepsisTaming lupus-a new understanding of pathogenesis is leading to clinical advances.C5a receptor signaling prevents folate deficiency-induced neural tube defects in miceStabilizing endothelium of donor hearts with fusogenic liposomes reduces myocardial injury and dysfunctionComplement in immune and inflammatory disorders: therapeutic interventions.Targeting complement component 5a promotes vascular integrity and limits airway remodelingComplement activation in pediatric patients with recurrent acute otitis media.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 06 May 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Inhibiting the C5-C5a receptor axis.
@en
Inhibiting the C5-C5a receptor axis.
@nl
type
label
Inhibiting the C5-C5a receptor axis.
@en
Inhibiting the C5-C5a receptor axis.
@nl
prefLabel
Inhibiting the C5-C5a receptor axis.
@en
Inhibiting the C5-C5a receptor axis.
@nl
P1433
P1476
Inhibiting the C5-C5a receptor axis.
@en
P2093
Francesco Tedesco
P304
P356
10.1016/J.MOLIMM.2011.04.014
P577
2011-05-06T00:00:00Z