Use of an oligoribonucleotide containing the polypurine tract sequence as a primer by HIV reverse transcriptase.
about
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNARNase H activity: structure, specificity, and function in reverse transcriptionRibonuclease H: properties, substrate specificity and roles in retroviral reverse transcriptionSelection of primer-template sequences that bind human immunodeficiency virus reverse transcriptase with high affinityComplexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradationMultiple nucleotide preferences determine cleavage-site recognition by the HIV-1 and M-MuLV RNases H.Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation.Effect of polypurine tract (PPT) mutations on human immunodeficiency virus type 1 replication: a virus with a completely randomized PPT retains low infectivity.Molecular requirements for human immunodeficiency virus type 1 plus-strand transfer: analysis in reconstituted and endogenous reverse transcription systems.Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation.HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.Sequence, distance, and accessibility are determinants of 5'-end-directed cleavages by retroviral RNases H.Relationship between plus strand DNA synthesis removal of downstream segments of RNA by human immunodeficiency virus, murine leukemia virus and avian myeloblastoma virus reverse transcriptasesHIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.Specific cleavages by RNase H facilitate initiation of plus-strand RNA synthesis by Moloney murine leukemia virus.Human immunodeficiency virus type 2 reverse transcriptase activity in model systems that mimic steps in reverse transcription.SiRNA-induced mutation in HIV-1 polypurine tract region and its influence on viral fitness.Sequence and structural determinants required for priming of plus-strand DNA synthesis by the human immunodeficiency virus type 1 polypurine tract.RNase H domain of Moloney murine leukemia virus reverse transcriptase retains activity but requires the polymerase domain for specificity.Discontinuous plus-strand DNA synthesis in human immunodeficiency virus type 1-infected cells and in a partially reconstituted cell-free systemA new role for HIV nucleocapsid protein in modulating the specificity of plus strand priming.Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein.Preferred sequences within a defined cleavage window specify DNA 3' end-directed cleavages by retroviral RNases HPolypurine tract formation by Ty1 RNase H.Polypurine tract primer generation and utilization by Moloney murine leukemia virus reverse transcriptase.Control of initiation of viral plus strand DNA synthesis by HIV reverse transcriptase.Alanine-scanning mutations in the "primer grip" of p66 HIV-1 reverse transcriptase result in selective loss of RNA priming activity.Interaction of p55 reverse transcriptase from the Saccharomyces cerevisiae retrotransposon Ty3 with conformationally distinct nucleic acid duplexes.Identification of a sequence element immediately upstream of the polypurine tract that is essential for replication of simian immunodeficiency virus.Incorporation of uracil into minus strand DNA affects the specificity of plus strand synthesis initiation during lentiviral reverse transcription.Extension and cleavage of the polypurine tract plus-strand primer by Ty1 reverse transcriptase.RNA degradation and primer selection by Moloney murine leukemia virus reverse transcriptase contribute to the accuracy of plus strand initiation.Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase.Analysis of plus-strand primer selection, removal, and reutilization by retroviral reverse transcriptases.
P2860
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P2860
Use of an oligoribonucleotide containing the polypurine tract sequence as a primer by HIV reverse transcriptase.
description
1995 nî lūn-bûn
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1995年の論文
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1995年学术文章
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1995年学术文章
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1995年学术文章
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1995年学术文章
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1995年学术文章
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name
Use of an oligoribonucleotide ...... by HIV reverse transcriptase.
@en
type
label
Use of an oligoribonucleotide ...... by HIV reverse transcriptase.
@en
prefLabel
Use of an oligoribonucleotide ...... by HIV reverse transcriptase.
@en
P2093
P356
P1476
Use of an oligoribonucleotide ...... by HIV reverse transcriptase.
@en
P2093
Bambara RA
Fuentes GM
Rodríguez-Rodríguez L
P304
28169-28176
P356
10.1074/JBC.270.47.28169
P407
P577
1995-11-01T00:00:00Z