Polypurine tract primer generation and utilization by Moloney murine leukemia virus reverse transcriptase.
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RNase H activity: structure, specificity, and function in reverse transcriptionRibonuclease H: properties, substrate specificity and roles in retroviral reverse transcriptionPCR inhibition by reverse transcriptase leads to an overestimation of amplification efficiency.Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture.Dynamic copy choice: steady state between murine leukemia virus polymerase and polymerase-dependent RNase H activity determines frequency of in vivo template switching.Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.Sequence, distance, and accessibility are determinants of 5'-end-directed cleavages by retroviral RNases H.Viral reverse transcriptases show selective high affinity binding to DNA-DNA primer-templates that resemble the polypurine tract.Specific cleavages by RNase H facilitate initiation of plus-strand RNA synthesis by Moloney murine leukemia virus.Human immunodeficiency virus type 2 reverse transcriptase activity in model systems that mimic steps in reverse transcription.Unique progressive cleavage mechanism of HIV reverse transcriptase RNase HPurine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis.Reverse transcriptase and integrase of the Saccharomyces cerevisiae Ty1 element.Polypurine tract formation by Ty1 RNase H.The role of template-primer in protection of reverse transcriptase from thermal inactivation.Mutating conserved residues in the ribonuclease H domain of Ty3 reverse transcriptase affects specialized cleavage events.Extension and cleavage of the polypurine tract plus-strand primer by Ty1 reverse transcriptase.RNA degradation and primer selection by Moloney murine leukemia virus reverse transcriptase contribute to the accuracy of plus strand initiation.The sequential mechanism of HIV reverse transcriptase RNase H.Generation and characterization of new highly thermostable and processive M-MuLV reverse transcriptase variants.Analysis of plus-strand primer selection, removal, and reutilization by retroviral reverse transcriptases.
P2860
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P2860
Polypurine tract primer generation and utilization by Moloney murine leukemia virus reverse transcriptase.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Polypurine tract primer genera ...... a virus reverse transcriptase.
@en
type
label
Polypurine tract primer genera ...... a virus reverse transcriptase.
@en
prefLabel
Polypurine tract primer genera ...... a virus reverse transcriptase.
@en
P2093
P2860
P356
P1476
Polypurine tract primer genera ...... a virus reverse transcriptase.
@en
P2093
Champoux JJ
Kelleher CD
Schultz SJ
P2860
P304
34547-34555
P356
10.1074/JBC.274.49.34547
P407
P577
1999-12-01T00:00:00Z