RNA degradation and primer selection by Moloney murine leukemia virus reverse transcriptase contribute to the accuracy of plus strand initiation.
about
RNase H activity: structure, specificity, and function in reverse transcriptionRibonuclease H: properties, substrate specificity and roles in retroviral reverse transcriptionMultiple nucleotide preferences determine cleavage-site recognition by the HIV-1 and M-MuLV RNases H.Mechanism analysis indicates that recombination events in HIV-1 initiate and complete over short distances, explaining why recombination frequencies are similar in different sections of the genomeDynamic copy choice: steady state between murine leukemia virus polymerase and polymerase-dependent RNase H activity determines frequency of in vivo template switching.Sequence, distance, and accessibility are determinants of 5'-end-directed cleavages by retroviral RNases H.Viral reverse transcriptases show selective high affinity binding to DNA-DNA primer-templates that resemble the polypurine tract.Specific cleavages by RNase H facilitate initiation of plus-strand RNA synthesis by Moloney murine leukemia virus.Unique progressive cleavage mechanism of HIV reverse transcriptase RNase HSiRNA-induced mutation in HIV-1 polypurine tract region and its influence on viral fitness.Substitution of alanine for tyrosine-64 in the fingers subdomain of M-MuLV reverse transcriptase impairs strand displacement synthesis and blocks viral replication in vivo.Identification of RNase-resistant RNAs in Saccharomyces cerevisiae extracts: Separation from chromosomal DNA by selective precipitation.A new role for HIV nucleocapsid protein in modulating the specificity of plus strand priming.Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein.Preferred sequences within a defined cleavage window specify DNA 3' end-directed cleavages by retroviral RNases HRequirements for DNA unpairing during displacement synthesis by HIV-1 reverse transcriptase.The sequential mechanism of HIV reverse transcriptase RNase H.Analysis of plus-strand primer selection, removal, and reutilization by retroviral reverse transcriptases.
P2860
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P2860
RNA degradation and primer selection by Moloney murine leukemia virus reverse transcriptase contribute to the accuracy of plus strand initiation.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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name
RNA degradation and primer sel ...... acy of plus strand initiation.
@en
RNA degradation and primer sel ...... acy of plus strand initiation.
@nl
type
label
RNA degradation and primer sel ...... acy of plus strand initiation.
@en
RNA degradation and primer sel ...... acy of plus strand initiation.
@nl
prefLabel
RNA degradation and primer sel ...... acy of plus strand initiation.
@en
RNA degradation and primer sel ...... acy of plus strand initiation.
@nl
P2860
P356
P1476
RNA degradation and primer sel ...... acy of plus strand initiation.
@en
P2093
Champoux JJ
Kelleher CD
P2860
P304
13061-13070
P356
10.1074/JBC.275.17.13061
P407
P577
2000-04-01T00:00:00Z