The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners.
about
KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferationThe histone demethylase LSD1/KDM1A promotes the DNA damage responseTherapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targetingLysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biologySIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cellsCatalytic mechanism investigation of lysine-specific demethylase 1 (LSD1): a computational studyOver-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancerReversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma.Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breastSmall-molecular modulators of cancer-associated epigenetic mechanisms.Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats.Histone Demethylases in Colon Cancer.Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/β-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected].Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking.Prognostic role of LSD1 in various cancers: evidence from a meta-analysisHistone demethylases and cancer.Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis.Overexpression of lysine specific demethylase 1 predicts worse prognosis in primary hepatocellular carcinoma patients.Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner.Cell cycle association of the retinoblastoma protein Rb and the histone demethylase LSD1 with the Epstein-Barr virus latency promoter Cp.Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells.Intersection of nuclear receptors and the proteasome on the epigenetic landscape.p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivoKDM1 is a novel therapeutic target for the treatment of gliomasProtein methylation: a new mechanism of p53 tumor suppressor regulation.Nuclear receptor coregulators as a new paradigm for therapeutic targeting.Upregulation of long intergenic noncoding RNA 00673 promotes tumor proliferation via LSD1 interaction and repression of NCALD in non-small-cell lung cancerPRMT5 is required for cell-cycle progression and p53 tumor suppressor function.Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.Polyamine analogues targeting epigenetic gene regulation.Emerging roles of epigenetic mechanisms in Parkinson's disease.Chromatin remodeling by polyamines and polyamine analogs.Lysine-specific modifications of p53: a matter of life and death?LSD1 inhibitors: a patent review (2010-2015).SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells.Synthesis, LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates.Relationship between LSD1 expression and E-cadherin expression in prostate cancer.NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect.
P2860
Q24311661-AA2FD41E-D504-4A15-9FF3-622BFCB00D84Q24339556-C8A89B5B-81BF-41C6-9DDD-34AEC35BE020Q26768602-2F76114E-F9FA-41E3-8EF8-E75A038DC979Q28269080-E044B071-8E32-4B36-845C-317119543893Q28468625-CDC8DB39-36E1-493A-BAF1-EE8102BEE10DQ28477309-596ADED5-E617-45CE-B7E1-D3A5EA9FA1B3Q28482156-103ADDC2-DBD5-4E43-AB95-C228DB9F1346Q34340537-6D6AD30F-3A97-4E05-BB39-48356E70B36AQ34392800-E6D9065A-64EF-4B75-9B19-9B9EEB1207ACQ34628002-0071DA30-049C-40B1-B762-F002071C566AQ34630230-6DCC6CA6-7B95-4D49-B9F2-185784D94B42Q34822197-98B97EE0-12D7-4673-99BE-BF7E1CF1301FQ34905762-AAA49A0F-CE75-47A7-B4CB-3211A336D3BEQ35086759-DB6AC417-6BE1-48BC-8AC6-ACBA7FBEA040Q35367028-B74B2B39-F3A0-4972-9D47-6875D9443DFAQ36116596-2C5E74D7-8541-4131-B66C-8543ECF8217CQ36421138-BD40506A-BF8B-4E77-AB1E-9677EEF6B031Q36434436-F7D7CD81-406C-47DD-A2C9-E165DE542432Q36450462-2070E283-A222-4E2D-946C-88C7D7A65B20Q36474544-4DD53C68-26FD-48D4-B234-B4147D040C23Q36498238-A948368F-8B30-4325-BA55-6C6AC4E39C8AQ36639638-25A0C100-A957-4B86-B3C6-7D28820C9065Q36759572-350724CA-02DF-4117-83AC-282EE301F684Q36788865-577F13FE-7719-47D1-8FB9-51C1AF2A415BQ36846083-5E57B95D-265F-4A74-AAAB-970072C86EE9Q36984826-A1A065FD-5B6B-4CCF-A138-601EAD36A1D3Q37200670-A33EEECD-2D35-4574-9AC4-6BC52D7B57D3Q37217158-83764815-9D8A-4A82-80E1-C735C886ED6CQ37295417-3FC8B327-2F1E-491C-AC6B-308DFE990420Q37318470-C06E24C6-B4BE-4A0D-A595-DBF6720AC7A9Q37436085-1A3FA253-5DF1-4596-9A7C-2975C310067FQ37679985-705F89E5-C891-443F-B60C-F8B3537F40FEQ37926552-8BC040BF-1AAA-4C3D-A553-38038007CE97Q38120212-4D4A9C8E-A102-4B59-8622-E93945F07380Q38168223-E6598458-08E6-4F1F-8227-2B4C0A7EC0BCQ38790899-F51F8A6C-376F-4A77-B943-6E8BA84237AFQ38852094-4263DFBF-6A4D-4C8B-8DBD-0C39A325F244Q38887327-C73E331F-3059-49AB-8D87-6C2DBCFDF007Q38915823-6EE89DA3-FA40-4A8D-8DAC-CDF017C88CC5Q38918211-8B517116-AF48-4BDC-B5F6-D4F598F0C443
P2860
The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The lysine-specific demethylas ...... dent and -independent manners.
@en
type
label
The lysine-specific demethylas ...... dent and -independent manners.
@en
prefLabel
The lysine-specific demethylas ...... dent and -independent manners.
@en
P2860
P356
P1476
The lysine-specific demethylas ...... dent and -independent manners.
@en
P2093
Ariane Scoumanne
Xinbin Chen
P2860
P304
15471-15475
P356
10.1074/JBC.M701023200
P407
P577
2007-04-04T00:00:00Z