A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation.
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Glanzmann thrombastheniaIntegrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesionsRIAM activates integrins by linking talin to ras GTPase membrane-targeting sequencesStructure-Guided Design of a High-Affinity Platelet Integrin IIb 3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDASSer-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombastheniaThe role of alpha and beta chains in ligand recognition by beta 7 integrinsA RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migrationBB0172, a Borrelia burgdorferi outer membrane protein that binds integrin α3β1.In vitro selection of fibronectin gain-of-function mutationsUrokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction.The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.Actual Role of Platelet Glycoprotein IIb/IIIa Receptor Inhibitors as Adjunctive Pharmacological Therapy to Primary Angioplasty in Acute Myocardial Infarction: In the Light of Recent Randomized Trials and Observational Studies with Bivalirudin.Inherited thrombocytopenia: novel insights into megakaryocyte maturation, proplatelet formation and platelet lifespan.Glanzmann thrombasthenia: state of the art and future directions.The alphaMbeta2 integrin and its role in neutrophil function.Divalent cations modulate alpha2beta1 integrin-mediated malignancy in a novel 3-dimensional in vitro model of pancreatic cancer.The α-subunit regulates stability of the metal ion at the ligand-associated metal ion-binding site in β3 integrins.The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms.Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb.Demystified...adhesion molecule deficiencies.Ligand bridging mediates integrin alpha IIb beta 3 (platelet GPIIB-IIIA) dependent homotypic and heterotypic cell-cell interactions.Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit associationA new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg----214Trp mutation.Homology modelling of integrin EF-hands. Evidence for widespread use of a conserved cation-binding siteRegulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the alpha 6 beta 1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages.Diagnosis of Glanzmann thrombasthenia by whole blood impedance analyzer (MEA) vs. light transmission aggregometry.A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.Three novel beta-propeller mutations causing Glanzmann thrombasthenia result in production of normally stable pro-alphaIIb, but variably impaired progression of pro-alphaIIbbeta3 from endoplasmic reticulum to GolgiHomologous recombination among three intragene Alu sequences causes an inversion-deletion resulting in the hereditary bleeding disorder Glanzmann thrombasthenia.An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen systemβ3 integrin interacts directly with GluA2 AMPA receptor subunit and regulates AMPA receptor expression in hippocampal neurons.Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin.Aquaporin 2 promotes cell migration and epithelial morphogenesis.A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogenDistinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions.Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin.Structure/function analysis of the integrin beta 1 subunit by epitope mapping.Integrin cytoplasmic domains mediate inside-out signal transduction.The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain.Integrin beta 3 cytoplasmic tail is necessary and sufficient for regulation of alpha 5 beta 1 phagocytosis by alpha v beta 3 and integrin-associated protein.
P2860
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P2860
A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh
1990年學術文章
@zh-hant
name
A beta 3 integrin mutation abo ...... cation-dependent conformation.
@en
type
label
A beta 3 integrin mutation abo ...... cation-dependent conformation.
@en
prefLabel
A beta 3 integrin mutation abo ...... cation-dependent conformation.
@en
P2093
P356
P1433
P1476
A beta 3 integrin mutation abo ...... cation-dependent conformation.
@en
P2093
Frelinger AL 3rd
Ginsberg MH
O'Toole TE
P304
P356
10.1126/SCIENCE.2392682
P407
P577
1990-08-01T00:00:00Z