Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.
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Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's diseaseMouse models of polyglutamine diseases: review and data table. Part IMaintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunctionExpression analysis of novel striatal-enriched genes in Huntington disease.Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease.Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease.Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysisTranscriptional activation of REST by Sp1 in Huntington's disease modelscAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in DrosophilaComprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation.Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats.Transcription, epigenetics and ameliorative strategies in Huntington's Disease: a genome-wide perspectiveComponents of the endocannabinoid and dopamine systems are dysregulated in Huntington's disease: analysis of publicly available microarray datasets.Experimental therapeutics in transgenic mouse models of Huntington's disease.Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington's DiseaseGlutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease.Development of novel therapies for Huntington's disease: hope and challenge.Molecular diagnosis of neurogenetic disorders involving trinucleotide repeat expansions.Novel therapeutic targets for Huntington's disease.Microarrays in Parkinson's disease: a systematic approach.Transcriptional signatures in Huntington's disease.Drug targeting of dysregulated transcription in Huntington's diseaseBrain-specific proteins decline in the cerebrospinal fluid of humans with Huntington diseaseA large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for huntington disease.Molecular mechanisms and potential therapeutical targets in Huntington's disease.Huntington's disease: can mice lead the way to treatment?DNA microarray analysis of hippocampal gene expression measured twelve hours after hypoxia-ischemia in the mouse.Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease.Sp1 regulates human huntingtin gene expression.Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor.Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.Context-dependent dysregulation of transcription by mutant huntingtin.Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunctionCGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model.Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis.cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues.Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease.Wild-type huntingtin protects neurons from excitotoxicity.
P2860
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P2860
Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Increased huntingtin protein l ...... odels of Huntington's disease.
@en
type
label
Increased huntingtin protein l ...... odels of Huntington's disease.
@en
prefLabel
Increased huntingtin protein l ...... odels of Huntington's disease.
@en
P2093
P50
P356
P1476
Increased huntingtin protein l ...... odels of Huntington's disease.
@en
P2093
Andrew Strand
Anne B Young
Edmond Y W Chan
James M Olson
Jang-Ho J Cha
Kathryn O Chase
Marian DiFiglia
Molly M DeJohn
Neil Aronin
Sarah A Hanson
P304
P356
10.1093/HMG/11.17.1939
P577
2002-08-01T00:00:00Z