Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases.
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SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreadingPhosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusionPTEN as an effector in the signaling of antimigratory G protein-coupled receptorPtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migrationCell polarity signaling in the plasticity of cancer cell invasivenessPtenb mediates gastrulation cell movements via Cdc42/AKT1 in zebrafishGenetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITORAllosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphatePlatelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinasesDystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophyA phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functionsTPIP: a novel phosphoinositide 3-phosphataseA phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migrationValidated prediction of pro-invasive growth factors using a transcriptome-wide invasion signature derived from a complex 3D invasion assayRational design and characterization of a Rac GTPase-specific small molecule inhibitorTargeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylationThe role of PTEN in prostate cancer cell tropism to the bone micro-environment.PTEN regulation of local and long-range connections in mouse auditory cortex.Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation.Protein kinase A regulates 3-phosphatidylinositide dynamics during platelet-derived growth factor-induced membrane ruffling and chemotaxisVitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation.Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblastsQuantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in DictyosteliumLoss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival.Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway.A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity.ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function.Redox modifier genes and pathways in amyotrophic lateral sclerosis.Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.Genomics of squamous cell lung cancerThe PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression.Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility.Mesenchymal migration as a therapeutic target in glioblastoma.Leukocytes navigate by compass: roles of PI3Kgamma and its lipid productsp53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cellsHypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species.PTEN Tumor Suppressor Network in PI3K-Akt Pathway ControlPTEN redundancy: overexpressing lpten, a homolog of Dictyostelium discoideum ptenA, the ortholog of human PTEN, rescues all behavioral defects of the mutant ptenA-
P2860
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P2860
Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Genetic deletion of the Pten t ...... ion of Rac1 and Cdc42 GTPases.
@en
type
label
Genetic deletion of the Pten t ...... ion of Rac1 and Cdc42 GTPases.
@en
prefLabel
Genetic deletion of the Pten t ...... ion of Rac1 and Cdc42 GTPases.
@en
P2093
P1433
P1476
Genetic deletion of the Pten t ...... ion of Rac1 and Cdc42 GTPases.
@en
P2093
J Liliental
R Mamillapalli
P304
P356
10.1016/S0960-9822(00)00417-6
P407
P577
2000-04-01T00:00:00Z